F
Fiona A. Ross
Researcher at University of Dundee
Publications - 30
Citations - 7576
Fiona A. Ross is an academic researcher from University of Dundee. The author has contributed to research in topics: AMPK & AMP-activated protein kinase. The author has an hindex of 23, co-authored 28 publications receiving 6498 citations.
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Journal ArticleDOI
AMPK: a nutrient and energy sensor that maintains energy homeostasis
TL;DR: AMP-activated protein kinase conserves ATP levels through the regulation of processes other than metabolism, such as the cell cycle and neuronal membrane excitability.
Journal ArticleDOI
Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
Simon A. Hawley,Fiona A. Ross,Cyrille Chevtzoff,Kevin A. Green,Ashleigh Evans,Sarah Fogarty,Mhairi C. Towler,Laura J. E. Brown,Oluseye A. Ogunbayo,A. Mark Evans,D. Grahame Hardie +10 more
TL;DR: The authors' approaches distinguish at least six different mechanisms for AMPK activation and confirm that the widely used antidiabetic drug metformin activates AMPK by inhibiting mitochondrial respiration.
Journal ArticleDOI
The ancient drug salicylate directly activates AMP-activated protein kinase
Simon A. Hawley,Morgan D. Fullerton,Fiona A. Ross,Jonathan D. Schertzer,Cyrille Chevtzoff,Katherine J. Walker,Mark Peggie,Darya Zibrova,Kevin A. Green,Kirsty J. Mustard,Bruce E. Kemp,Kei Sakamoto,Gregory R. Steinberg,Gregory R. Steinberg,D. Grahame Hardie +14 more
TL;DR: The results suggest that AMPK activation could explain some beneficial effects of salsalate and aspirin in humans, and a possible molecular mechanism of action for a metabolite of aspirin is described.
Journal ArticleDOI
AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation
TL;DR: AMP is a true physiological regulator of AMPK, and allosteric regulation is an important component of the overall activation mechanism.
Journal ArticleDOI
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
Olga Göransson,Andrew McBride,Simon A. Hawley,Fiona A. Ross,Natalia Shpiro,Marc Foretz,Marc Foretz,Benoit Viollet,Benoit Viollet,D. Grahame Hardie,Kei Sakamoto +10 more
TL;DR: The results show that in intact cells, the effects of A-769662 are independent of the upstream kinase utilized, and it is proposed that this direct and specific AMPK activator will be a valuable experimental tool to understand the physiological roles of AMPK.