K
Kevin A. Janes
Researcher at University of Virginia
Publications - 97
Citations - 7418
Kevin A. Janes is an academic researcher from University of Virginia. The author has contributed to research in topics: Biology & Signal transduction. The author has an hindex of 31, co-authored 82 publications receiving 6829 citations. Previous affiliations of Kevin A. Janes include Harvard University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Chitosan-DNA nanoparticles as gene carriers : synthesis, characterization and transfection efficiency
Hai-Quan Mao,Krishnendu Roy,Vu L. Troung-Le,Kevin A. Janes,Kevin Y. Lin,Yan Wang,J. Thomas August,Kam W. Leong +7 more
TL;DR: The chitosan-DNA nanoparticles could partially protect the encapsulated plasmid DNA from nuclease degradation as shown by electrophoretic mobility analysis and three different schemes to conjugate transferrin or KNOB protein to the nanoparticle surface were developed.
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Polysaccharide colloidal particles as delivery systems for macromolecules.
TL;DR: This article reviews the approaches which have aimed to associate macromolecules to chitosan in the form of colloidal structures and analyzes the evidence of their efficacy in improving the transport of the associated molecule through mucosae and epithelia.
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Chitosan nanoparticles as delivery systems for doxorubicin
TL;DR: Preliminary studies showed the feasibility of chitosan nanoparticles to entrap the basic drug DOX and to deliver it into the cells in its active form.
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A Systems Model of Signaling Identifies a Molecular Basis Set for Cytokine-Induced Apoptosis
Kevin A. Janes,John G. Albeck,Suzanne Gaudet,Peter K. Sorger,Douglas A. Lauffenburger,Michael B. Yaffe +5 more
TL;DR: A systems model of 7980 intracellular signaling events that directly links measurements to 1440 response outputs associated with apoptosis revealed new molecular mechanisms connecting signaling to apoptosis, suggesting that cell survival is determined by signaling through this canonical basis set.
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Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice
A. Vila,Alejandro Sánchez,Kevin A. Janes,Isabel Behrens,Thomas Kissel,José Luis Vila Jato,María J. Alonso +6 more
TL;DR: Interestingly, the ability of these nanoparticles to provide improved access to the associated antigen to the immune system was not significantly affected by the CS Mw, and high and long-lasting responses could be obtained using low Mw CS molecules.