Journal ArticleDOI
Chitosan nanoparticles as delivery systems for doxorubicin
TLDR
Preliminary studies showed the feasibility of chitosan nanoparticles to entrap the basic drug DOX and to deliver it into the cells in its active form.About:
This article is published in Journal of Controlled Release.The article was published on 2001-06-15. It has received 704 citations till now. The article focuses on the topics: Drug carrier & Chitosan.read more
Citations
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Biodegradable polymeric nanoparticles based drug delivery systems
TL;DR: The impact of nanoencapsulation of various disease related drugs on biodegradable nanoparticles such as PLGA, PLA, chitosan, gelatin, polycaprolactone and poly-alkyl-cyanoacrylates is highlighted.
Journal ArticleDOI
Chitosan chemistry and pharmaceutical perspectives.
TL;DR: Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. S. Nagar, Punjab-160 062, India, Institute of Biochemistry, Faculty of Medicine, Polytechnic University, Via Ranieri 67, IT-60100 Ancona, Italy, and Department of Medicinal Chemistry & Natural Products,The Hebrew University of Jerusalem, School of Pharmacy-Faculty of medicine, Jerusalem 91120, Israel.
Journal ArticleDOI
Recent advances on chitosan-based micro- and nanoparticles in drug delivery.
TL;DR: The present review outlines the major new findings on the pharmaceutical applications of chitosan-based micro/nanoparticulate drug delivery systems published over the past decade and discusses critically the usefulness of these systems in delivering the bioactive molecules.
Journal ArticleDOI
Chitosan—A versatile semi-synthetic polymer in biomedical applications
TL;DR: The chemical structure and relevant biological properties of chitosan for regenerative medicine have been summarized as well as the methods for the preparation of controlled drug release devices and their applications.
Journal ArticleDOI
Novel crosslinking methods to design hydrogels
Wim E. Hennink,C.F. van Nostrum +1 more
TL;DR: In this overview, different chemical and physical crosslinking methods used for the design of biodegradable hydrogels are summarized and discussed.
References
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Journal ArticleDOI
Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers
TL;DR: In this paper, a new approach for the preparation of nanoparticles made solely of hydrophilic polymers is presented, based on an ionic gelation process, is extremely mild and involves the mixture of two aqueous phases at room temperature.
Journal ArticleDOI
Expression of Multidrug Resistance Gene in Human Cancers
Lori J. Goldstein,Hanan Galski,Antonio Tito Fojo,Mark C. Willingham,Shinn Lian Lai,Adi F. Gazdar,Robert Pirker,Alexander A. Green,William M. Crist,Garrett M. Brodeur,Michael M. Lieber,Jeffrey Cossman,Michael M. Gottesman,Ira Pastan +13 more
TL;DR: Evaluation of MDR1 gene expression may prove to be a valuable tool in the identification of individuals whose cancers are resistant to specific agents, and the information may be useful in designing or altering chemotherapeutic protocols in these patients.
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Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2).
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Enhancement of nasal absorption of insulin using chitosan nanoparticles.
TL;DR: Insulin association was found to be highly mediated by an ionic interaction mechanism and its release in vitro occurred rapidly in sink conditions, and chitosan nanoparticles are efficient vehicles for the transport of insulin through the nasal mucosa.
Journal ArticleDOI
Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles
A. E. Gulyaev,Svetlana Gelperina,I. N. Skidan,Arkady S. Antropov,Gregory Ya. Kivman,Jörg Kreuter +5 more
TL;DR: It is demonstrated that the brain concentration of systemically administered doxorubicin can be enhanced over 60-fold by binding to biodegradable poly(butyl cyanoacrylate) nanoparticles, overcoated with the nonionic surfactant polysorbate 80.