K
Kevin B. Bahnck
Researcher at Pfizer
Publications - 19
Citations - 617
Kevin B. Bahnck is an academic researcher from Pfizer. The author has contributed to research in topics: Lipophilic efficiency & Indole test. The author has an hindex of 10, co-authored 19 publications receiving 581 citations. Previous affiliations of Kevin B. Bahnck include University of California, Irvine & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
Bond insertion, complexation, and penetration pathways of vapor-deposited aluminum atoms with HO- and CH3O-terminated organic monolayers
Gregory L. Fisher,Amy V. Walker,Andy E. Hooper,Timothy B. Tighe,Kevin B. Bahnck,Hope T. Skriba,Michael D. Reinard,Brendan C. Haynie,Robert L. Opila,Nicholas Winograd,David L. Allara +10 more
TL;DR: It is suggested that the competition between the penetration and overlayer film nucleation channels is regulated by small differences in the Al-SAM terminal group interaction energies, which point to a new perspective on organometallic and metal-solvent interactions.
Journal ArticleDOI
Synthesis of sulfones from organozinc reagents, DABSO, and alkyl halides.
Benjamin N. Rocke,Kevin B. Bahnck,Michael Herr,Sophie Y. Lavergne,Vincent Mascitti,Christian Perreault,Jana Polivkova,Andrei Shavnya +7 more
TL;DR: Organozinc reagents react with the SO2 surrogate DABSO, and the resulting zinc sulfinate salts are alkylated in situ to afford sulfones, compatible with a wide range of structural motifs of medicinal chemistry relevance including nitrile, secondary carbamates, and nitrogen-containing heterocycles.
Journal ArticleDOI
Indolynes as electrophilic indole surrogates: fundamental reactivity and synthetic applications.
TL;DR: A mild method to access a variety of substituted indole derivatives has been developed that relies on the generation of highly reactive indolyne intermediates, which function as electrophilic indole surrogates.
Journal ArticleDOI
Rapid stereocontrolled assembly of the fully substituted C-aryl glycoside of kendomycin with a Prins cyclization: a formal synthesis
TL;DR: Prins cyclization using an electron-rich benzaldehyde and a homoallylic alcohol efficiently delivered the fully substituted C-aryl tetrahydropyranoside of kendomycin.
Journal ArticleDOI
Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure
David A. Griffith,Robert L. Dow,Kim Huard,David J. Edmonds,Scott W. Bagley,Jana Polivkova,Dongxiang Zeng,Carmen N. Garcia-Irizarry,James A. Southers,William P. Esler,Paul A. Amor,Kathrine Loomis,Kirk McPherson,Kevin B. Bahnck,Cathy Préville,Tereece Banks,Dianna E. Moore,Alan M. Mathiowetz,Elnaz Menhaji-Klotz,Aaron C. Smith,Shawn D. Doran,David A. Beebe,Matthew F. Dunn +22 more
TL;DR: The lactam series has improved chemical and metabolic stability relative to the previously reported pyrazoloketone series, while retaining potent inhibition of ACC1 and ACC2.