Kevin Duff

TL;DR: The findings from the Predict-HD study suggest the approximate time scale of measurable disease development, and suggest candidate disease markers for use in preventive HD trials.

TL;DR: In this paper, the authors examined self-reported psychiatric symptoms in a large sample (N = 681) of prediagnosed individuals who show the gene expansion for HD (expansion-positive) compared with a sample of individuals who do not show gene expansion but are at risk for HD, and found that expansion-positive individuals reported significantly more psychiatric symptoms (e.g., depression, anxiety, obsessive compulsiveness) than expansion-negative individuals.

TL;DR: Neurocognitive tests are robust clinical indicators of the disease process prior to reaching criteria for motor diagnosis of HD.

TL;DR: Serial assessment with alternate forms may attenuate retest effects on some tests, but continued learning occurs on novel tests or those in which an advantageous test-taking strategy can be identified.

TL;DR: A review of the relevant concepts and methods used in repeated neuropsychological evaluations can be found in this paper, where the focus is on the understanding and application of these concepts in the evaluation of the individual patient through examples.