J
Jane S. Paulsen
Researcher at University of Wisconsin-Madison
Publications - 367
Citations - 29118
Jane S. Paulsen is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Huntington's disease & Cognition. The author has an hindex of 83, co-authored 355 publications receiving 26145 citations. Previous affiliations of Jane S. Paulsen include MedStar Georgetown University Hospital & University of California, San Diego.
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Journal ArticleDOI
Unified huntington’s disease rating scale: Reliability and consistency
Karl Kieburtz,John B. Penney,Peter Corno,Neal G. Ranen,Ira Shoulson,Andrew Feigin,Davi Abwender,J. Timothy Greenarnyre,Donald S. Higgins,Frederick J. Marshall,Joshua L. Goldstein,Kimberly Steinberg,Charles Shih,Irene H. Richard,Charlyne Hickey,Carol Zimmerman,Constance Orme,Kathy Claude,David Oakes,Daniel S. Sax,Anthony Kim,Steven M. Hersch,Randi Jones,Alexander P. Auchus,David B. Olsen,Cheryl Bissey-Black,Allen Rubin,Rose Schwartz,Richard Dubinsky,William Mallonee,Carolyn Gray,Nan Godfrey,Greg Suter,Kathleen M. Shannon,Glenn T. Stebbins,Jean A. Jaglin,Karen Marder,Stuart Taylor,Elan D. Louis,Carol Moskowitz,Deborah Zeck Thorne,Naomi Zubin,Nancy S. Wexler,Michael R. Swenson,Jane S. Paulsen,Neal R. Swerdlow,Roger L. Albin,Christine Wernette,Francis O. Walker,Vicki Hunt +49 more
TL;DR: The limited longitudinal database indicates that the UHDRS may be useful for tracking changes in the clinical features of HD over time and there was an excellent degree of interrater reliability for the motor scores.
Journal ArticleDOI
Huntington disease: natural history, biomarkers and prospects for therapeutics
Christopher A. Ross,Elizabeth Aylward,Edward J. Wild,Douglas R. Langbehn,Jeffrey D. Long,John H. Warner,Rachael I. Scahill,Blair R. Leavitt,Julie C. Stout,Jane S. Paulsen,R Reilmann,Paul G. Unschuld,Alice Wexler,Russell L. Margolis,Sarah J. Tabrizi +14 more
TL;DR: The natural history of HD is described, including the timing of emergence of motor, cognitive and emotional impairments, and the techniques that are used to assess these features, and potential future roles of these biomarkers in clinical trials are reviewed.
Journal ArticleDOI
A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length.
TL;DR: A parametric survival model based on CAG repeat length is developed to predict the probability of neurological disease onset (based on motor neurological symptoms rather than psychiatric onset) at different ages for individual patients using the largest cohort of HD patients analyzed to date.
Journal ArticleDOI
Detection of Huntington’s disease decades before diagnosis: The Predict HD study
Jane S. Paulsen,Douglas R. Langbehn,Julie C. Stout,Elizabeth Aylward,Christopher A. Ross,Martha Nance,Mark Guttman,Shannon A. Johnson,Marcy E. MacDonald,Leigh J. Beglinger,Kevin Duff,Elise Kayson,Kevin M. Biglan,Ira Shoulson,David Oakes,Michael R. Hayden +15 more
TL;DR: The findings from the Predict-HD study suggest the approximate time scale of measurable disease development, and suggest candidate disease markers for use in preventive HD trials.
Journal ArticleDOI
Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset
Nancy S. Wexler,Judith Lorimer,Julie Porter,Fidela Gomez,Carol Moskowitz,Edith Shackell,Karen Marder,Penchaszadeh Gk,Simone A. Roberts,Javier Gayán,Denise Brocklebank,Stacey S. Cherny,Lon R. Cardon,Jacqueline Gray,Stephen R. Dlouhy,Sandra Wiktorski,Marion E. Hodes,P. Michael Conneally,J. B. Penney,James F. Gusella,Jang Ho Cha,Michael C. Irizarry,Diana Rosas,Steven M. Hersch,Zane R. Hollingsworth,Marcy E. MacDonald,Anne B. Young,J. Michael Andresen,David E. Housman,Margot de Young,Ernesto Bonilla,Theresa Stillings,Américo Negrette,S. Robert Snodgrass,Maria Dolores Martinez-Jaurrieta,Maria A. Ramos-Arroyo,Jacqueline Bickham,Juan Sanchez Ramos,Frederick J. Marshall,Ira Shoulson,Gustavo Rey,Andrew Feigin,Norman Arnheim,Amarilis Acevedo-Cruz,Leticia Acosta,Jose Alvir,Kenneth H. Fischbeck,Leslie M. Thompson,Angela Young,Leon S. Dure,Christopher J. O'Brien,Jane S. Paulsen,Adam M. Brickman,Denise Krch,Shelley Peery,Penelope Hogarth,Donald S. Higgins,Bernhard Landwehrmeyeri +57 more
TL;DR: A model estimated the components of additive genetic, shared environment, and nonshared environment variances confirming that approximately 40% of the variance remaining in onset age is attributable to genes other than the HD gene and 60% is environmental.