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Kevin J. Whitehead
Researcher at University of Utah
Publications - 75
Citations - 4085
Kevin J. Whitehead is an academic researcher from University of Utah. The author has contributed to research in topics: Medicine & Vascular malformation. The author has an hindex of 25, co-authored 65 publications receiving 3113 citations. Previous affiliations of Kevin J. Whitehead include Center for Excellence in Education & Veterans Health Administration.
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Journal ArticleDOI
Hereditary hemorrhagic telangiectasia: genetics and molecular diagnostics in a new era.
Jamie McDonald,Whitney Wooderchak-Donahue,Whitney Wooderchak-Donahue,Chad VanSant Webb,Kevin J. Whitehead,David A. Stevenson,Pinar Bayrak-Toydemir,Pinar Bayrak-Toydemir +7 more
TL;DR: An expanded approach to molecular diagnostics for inherited telangiectasia disorders that incorporates a multi-gene next generation sequencing (NGS) HHT panel is proposed.
Journal ArticleDOI
The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases
Kevin J. Whitehead,Aubrey C. Chan,Sutip Navankasattusas,Wonshill Koh,Nyall London,Jing Ling,Anne M. Mayo,Stavros G. Drakos,Douglas A. Marchuk,George E. Davis,Dean Y. Li +10 more
TL;DR: It is shown that targeted disruption of Ccm2 in mice results in failed lumen formation and early embryonic death through an endothelial cell autonomous mechanism, and the prospect for pharmacological treatment of a human vascular dysplasia with a widely available and safe drug is offered.
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Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.
Amy Akers,Rustam Al-Shahi Salman,Issam A. Awad,Kristen Dahlem,Kelly D. Flemming,Blaine L. Hart,Helen Kim,Ignacio Jusué-Torres,Douglas Kondziolka,Cornelia Lee,Leslie Morrison,Daniele Rigamonti,Tania Rebeiz,Elisabeth Tournier-Lasserve,Darrel Waggoner,Kevin J. Whitehead +15 more
TL;DR: Current evidence supports recommendations for the management of CCM, but their generally low levels and classes mandate further research to better inform clinical practice and update these recommendations.
Journal ArticleDOI
Endothelial TLR4 and the microbiome drive cerebral cavernous malformations
Alan T. Tang,Jaesung P. Choi,Jonathan J. Kotzin,Yiqing Yang,Courtney C. Hong,Nicholas Hobson,Romuald Girard,Hussein A. Zeineddine,Rhonda Lightle,Thomas R. Moore,Ying Cao,Robert Shenkar,Mei Chen,Patricia Mericko,Jisheng Yang,Li Li,Ceylan Tanes,Dmytro Kobuley,Urmo Võsa,Kevin J. Whitehead,Dean Y. Li,Lude Franke,Blaine L. Hart,Markus Schwaninger,Jorge Henao-Mejia,Jorge Henao-Mejia,Leslie Morrison,Helen Kim,Issam A. Awad,Xiangjian Zheng,Xiangjian Zheng,Mark L. Kahn +31 more
TL;DR: These studies identify unexpected roles for the microbiome and innate immune signalling in the pathogenesis of a cerebrovascular disease, as well as strategies for its treatment.
Journal ArticleDOI
Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling
Zinan Zhou,Alan T. Tang,Weng Yew Wong,Sharika Bamezai,Lauren M. Goddard,Robert Shenkar,Su Zhou,Jisheng Yang,Alexander C. Wright,Matthew Foley,J. Simon C. Arthur,Kevin J. Whitehead,Issam A. Awad,Dean Y. Li,Dean Y. Li,Xiangjian Zheng,Mark L. Kahn +16 more
TL;DR: These studies identify gain of MEKK3 signalling and KLF2/4 function as causal mechanisms for CCM pathogenesis that may be targeted to develop new CCM therapeutics.