Dmytro Kobuley

TL;DR: Results identify a previously unrecognized pathway through which commensal-derived signals influence basophil hematopoiesis and susceptibility to TH2 cytokine–dependent inflammation and allergic disease.

TL;DR: An oral antibiotic treatment protocol is developed and characterized its effects on murine intestinal bacterial communities and immune cell homeostasis and metagenomic analyses will provide a resource and framework to test the influence of bacterial communities in murine models of human disease.

TL;DR: It is proposed that acquisition of, or alterations in, commensal bacteria influences intestinal immune homeostasis via direct regulation of the IL-25–IL-23– IL-17 axis.

TL;DR: Data indicate that helminth-induced immunomodulation occurs independently of changes in the microbiota but is dependent on Ym1, a chitinase-like molecule that is associated with alternatively activated macrophages, which could partially restore antiviral immunity.

TL;DR: These studies identify unexpected roles for the microbiome and innate immune signalling in the pathogenesis of a cerebrovascular disease, as well as strategies for its treatment.