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Xiangjian Zheng
Researcher at Tianjin Medical University
Publications - 45
Citations - 2009
Xiangjian Zheng is an academic researcher from Tianjin Medical University. The author has contributed to research in topics: Medicine & Phospholipase D. The author has an hindex of 20, co-authored 37 publications receiving 1546 citations. Previous affiliations of Xiangjian Zheng include University of Pennsylvania & Georgia Regents University.
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Journal ArticleDOI
Endothelial TLR4 and the microbiome drive cerebral cavernous malformations
Alan T. Tang,Jaesung P. Choi,Jonathan J. Kotzin,Yiqing Yang,Courtney C. Hong,Nicholas Hobson,Romuald Girard,Hussein A. Zeineddine,Rhonda Lightle,Thomas R. Moore,Ying Cao,Robert Shenkar,Mei Chen,Patricia Mericko,Jisheng Yang,Li Li,Ceylan Tanes,Dmytro Kobuley,Urmo Võsa,Kevin J. Whitehead,Dean Y. Li,Lude Franke,Blaine L. Hart,Markus Schwaninger,Jorge Henao-Mejia,Jorge Henao-Mejia,Leslie Morrison,Helen Kim,Issam A. Awad,Xiangjian Zheng,Xiangjian Zheng,Mark L. Kahn +31 more
TL;DR: These studies identify unexpected roles for the microbiome and innate immune signalling in the pathogenesis of a cerebrovascular disease, as well as strategies for its treatment.
Journal ArticleDOI
Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling
Zinan Zhou,Alan T. Tang,Weng Yew Wong,Sharika Bamezai,Lauren M. Goddard,Robert Shenkar,Su Zhou,Jisheng Yang,Alexander C. Wright,Matthew Foley,J. Simon C. Arthur,Kevin J. Whitehead,Issam A. Awad,Dean Y. Li,Dean Y. Li,Xiangjian Zheng,Mark L. Kahn +16 more
TL;DR: These studies identify gain of MEKK3 signalling and KLF2/4 function as causal mechanisms for CCM pathogenesis that may be targeted to develop new CCM therapeutics.
Journal ArticleDOI
Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway
Benjamin Kleaveland,Xiangjian Zheng,Jian J. Liu,Yannick Blum,Jennifer J. Tung,Zhiying Zou,Shawn M. Sweeney,Mei Chen,Lili Guo,MinMin Lu,Diane Zhou,Jan Kitajewski,Markus Affolter,Mark H. Ginsberg,Mark L. Kahn +14 more
TL;DR: It is shown that the heart of glass (HEG1) receptor, which in zebrafish has been linked to ccm gene function, is selectively expressed in endothelial cells, and is identified as a crucial regulator of heart and vessel formation and integrity.
Journal ArticleDOI
CCM3 signaling through sterile 20–like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations
Xiangjian Zheng,Chong Xu,Annarita Di Lorenzo,Benjamin Kleaveland,Zhiying Zou,Christoph Seiler,Mei Chen,Lan Cheng,Jiping Xiao,Jie He,Michael Pack,William C. Sessa,Mark L. Kahn +12 more
TL;DR: STKs are identified as essential downstream effectors of CCM signaling in development and disease that may regulate both endothelial and epithelial cell junctions and stk deficiency and combined low-level deficiency of stks and ccm3 in zebrafish embryos.
Journal ArticleDOI
The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression
Zinan Zhou,David R. Rawnsley,Lauren M. Goddard,Wei Pan,Xing Jun Cao,Zoltán Jakus,Hui Zheng,Jisheng Yang,J. Simon C. Arthur,Kevin J. Whitehead,Dean Y. Li,Dean Y. Li,Bin Zhou,Benjamin A. Garcia,Xiangjian Zheng,Xiangjian Zheng,Mark L. Kahn +16 more
TL;DR: It is shown that loss of CCM signaling in endocardial cells results in mid-gestation heart failure associated with premature degradation of cardiac jelly, and the findings reveal a molecular mechanism by whichCCM signaling controls endothelial gene expression during cardiovascular development that may also underlie CCM formation.