K
Kevin J. Yarema
Researcher at Johns Hopkins University
Publications - 140
Citations - 6166
Kevin J. Yarema is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Sialic acid & Glycosylation. The author has an hindex of 43, co-authored 134 publications receiving 5548 citations. Previous affiliations of Kevin J. Yarema include Massachusetts Institute of Technology & Johns Hopkins University School of Medicine.
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Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis
TL;DR: The versatility of this technology was demonstrated by an example of selective drug delivery, where cells were decorated with biotin through selective conjugation to ketone groups, and selectively killed in the presence of a ricin A chain-avidin conjugate.
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Metabolic Glycoengineering: Sialic Acid and Beyond
TL;DR: Recently, sialic acid glycoengineering methodology has been extended to other pathways with analog incorporation now possible in surface-displayed GalNAc and fucose residues as well as nucleocytoplasmic O-GlcNAc-modified proteins.
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The effect of nanofiber-guided cell alignment on the preferential differentiation of neural stem cells.
TL;DR: A mechanism by which morphological control of stem cells operates in concert with biochemical cues for cell fate determination is suggested, by which aligned substratum topography influences the cell morphology and subsequently, the neuronal differentiation capabilities of adult neural stem cells.
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Analysis of Incision Sites Produced by Human Cell Extracts and Purified Proteins during Nucleotide Excision Repair of a 1,3-Intrastrand d(GpTpG)-Cisplatin Adduct
TL;DR: Oligonucleotides were formed at the same rate as the 3′ cleavage, suggesting that both incisions are made in a near-synchronous manner, and there was, however, a low frequency of 5′ incisions in the absence of 3′ Cleavage.
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Metabolic Delivery of Ketone Groups to Sialic Acid Residues APPLICATION TO CELL SURFACE GLYCOFORM ENGINEERING
TL;DR: A general strategy for engineering the display of chemically defined oligosaccharides on cell surfaces that combines the concepts of metabolic engineering and selective chemical reactivity is described.