Jonathan G. Moggs

TL;DR: Results demonstrate that the XPF, ERCC4, and ERCC11 genes are equivalent, complete the isolation of the XP genes that form the core nucleotide excision repair system, and solve the catalytic function of theXPF-containing complex.

TL;DR: Analysis of mechanism of open complex formation finds that mutations in XPB or XPD, the DNA helicase subunits of the transcription and repair factor TFIIH, can completely prevent opening and dual incision in cell‐free extracts, and supports a mechanism in whichTFIIH‐associated helicase activity and XPC protein catalyze initial formation of the key open intermediate.

TL;DR: It is shown that XPG makes a structure-specific endonucleolytic incision in a synthetic DNA substrate containing a duplex region and single-stranded arms, by cleaving 3' to DNA damage during nucleotide excision repair.

TL;DR: This work provides the first evidence for the potential use of miRNAs as biomarkers of human drug‐induced liver injury by examining these molecules, for the first time, in humans with APAP poisoning.

TL;DR: Elevations in plasma miR‐122, HMGB1, and necrosis K18 identified subsequent ALI development in patients on admission to the hospital, soon after acetaminophen overdose, and in patients with ALTs in the normal range.