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Kevin P. Rioux
Researcher at University of Calgary
Publications - 53
Citations - 4021
Kevin P. Rioux is an academic researcher from University of Calgary. The author has contributed to research in topics: Ulcerative colitis & Inflammatory bowel disease. The author has an hindex of 25, co-authored 53 publications receiving 3337 citations.
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Journal ArticleDOI
Risk of Surgery for Inflammatory Bowel Diseases Has Decreased Over Time: A Systematic Review and Meta-analysis of Population-Based Studies
Alexandra D. Frolkis,Jonathan Dykeman,Maria Negron,Jennifer deBruyn,Nathalie Jette,Kirsten M. Fiest,Talia Frolkis,Herman W. Barkema,Kevin P. Rioux,Remo Panaccione,Subrata Ghosh,Samuel Wiebe,Gilaad G. Kaplan +12 more
TL;DR: The risk of intestinal surgery among patients with IBD has decreased over the past 6 decades, and the trend in risk of surgery over time was analyzed by meta-regression using mixed-effect models.
Journal ArticleDOI
Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease
Maitreyi Raman,Iftikhar Ahmed,Patrick M. Gillevet,Chris Probert,Norman M. Ratcliffe,S. Smith,Rosemary Greenwood,Masoumeh Sikaroodi,Victor Lam,Pam Crotty,Jennifer Bailey,Robert P. Myers,Kevin P. Rioux +12 more
TL;DR: A significant increase in fecal ester VOC is associated with compositional shifts in the microbiome of obese NAFLD patients, and these novel bacterial metabolomic and metagenomic factors are implicated in the etiology and complications of obesity.
Journal ArticleDOI
Invasive potential of gut mucosa-derived Fusobacterium nucleatum positively correlates with IBD status of the host.
Jaclyn Strauss,Gilaad G. Kaplan,Paul L. Beck,Kevin P. Rioux,Remo Panaccione,Rebekah DeVinney,Tarah Lynch,Emma Allen-Vercoe +7 more
TL;DR: This study indicates that colonization of the intestinal mucosa by highly invasive strains of F. nucleatum may be a useful biomarker for gastrointestinal disease.
Journal ArticleDOI
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
Simon A. Hirota,Jeffrey Ng,Alan Lueng,Maitham A. Khajah,Ken Kuljit S. Parhar,Yan Li,Victor Lam,Mireille S. Potentier,Kelvin Ng,Misha Bawa,Donna-Marie McCafferty,Kevin P. Rioux,Subrata Ghosh,Ramnik J. Xavier,Sean P. Colgan,Jürg Tschopp,Daniel A. Muruve,Justin A. MacDonald,Paul L. Beck +18 more
TL;DR: An essential role for the NLRP3 inflammasome is confirmed in the maintenance of intestinal homeostasis through its regulation of innate protective processes and biological insight into disease mechanisms associated with increased risk of CD in individuals withNLRP3 mutations is provided.
Journal ArticleDOI
The human gut microbiome: current knowledge, challenges, and future directions
TL;DR: Next-generation sequencing technologies combined with advanced bioinformatics place us at the doorstep of revolutionary insight into the composition, capability, and activity of the human intestinal microbiome.