Kevin Rychel

TL;DR: iModulonDB (imodulondb.org), a knowledgebase of prokaryotic transcriptional regulation computed from high-quality transcriptomic datasets using ICA, is presented, enhancing research by presenting scientists of all backgrounds with co-expressed gene sets and their activity levels.

TL;DR: The TRN structure and its condition-dependent activity uncover putative or recently discovered roles for at least five regulons, such as a relationship between histidine utilization and quorum sensing, and facilitates quantification of population-level sporulation states.

TL;DR: iModulonDB (imodulondb.org), a knowledgebase of prokaryotic transcriptional regulation computed from high-quality transcriptomic datasets using ICA, is presented, enhancing research by presenting scientists of all backgrounds with co-expressed gene sets and their activity levels.

TL;DR: The TRN structure and its condition-dependent activity uncover novel or recently discovered roles for at least 5 regulons, such as a relationship between histidine utilization and quorum sensing, and facilitates quantification of population-level sporulation states.

TL;DR: Findings lend deeper mechanistic insight into how biomaterials can be designed to fine-tune outcomes like differentiation, migration, and collective morphogenesis.