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Khalid Ouararhni

Researcher at Khalifa University

Publications -  28
Citations -  2037

Khalid Ouararhni is an academic researcher from Khalifa University. The author has contributed to research in topics: Chromatin & Nucleosome. The author has an hindex of 15, co-authored 23 publications receiving 1685 citations. Previous affiliations of Khalid Ouararhni include Centre national de la recherche scientifique & University of Strasbourg.

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The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

Pascal Drané, +4 more
- 15 Jun 2010 - 
TL;DR: The data demonstrate that DAXX functions as a bona fide histone chaperone involved in the replication-independent deposition of H3.3, establishing a new link between the PML bodies and the regulation of pericentric DNA repeat chromatin structure.
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ANP32E is a histone chaperone that removes H2A.Z from chromatin

Arnaud Obri, +12 more
- 30 Jan 2014 - 
TL;DR: It is shown that ANP32E is a member of the presumed H2A.Z histone-exchange complex p400/TIP60, and the crystal structure of the complex formed between the ANP 32E-ZID and the H2 a.Z/H2B dimer and biochemical data support an underlying molecular mechanism for H2 A.Z deposition and removal from chromatin.
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HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres

Muhammad Shuaib, +3 more
- 26 Jan 2010 - 
TL;DR: It is found that HJURP, a member of the complex, was required for cell cycle specific targeting of CENP-A to centromeres, and the novel characteristic identified in vertebrates that was named TLTY box of CBD, was essential for formation of the HJurP-CENp-A/H4 complex.
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Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma

Benjamin Herquel, +12 more
- 17 May 2011 - 
TL;DR: It is demonstrated that the TIF1-related subfamily of TRIM proteins interact both physically and functionally to modulate HCC formation in mice.
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The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity

Khalid Ouararhni, +7 more
- 01 Dec 2006 - 
TL;DR: The data presented point to a novel mechanism for control of Hsp70.1 gene transcription by using chromatin immunoprecipitation and tandem affinity immunopurification of the mH2A1.1 nucleosome complex, which was demonstrated and found to be associated with inactivation of PARP-1 enzyme activity.