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Patrick T. Reilly
Researcher at University of Strasbourg
Publications - 27
Citations - 1686
Patrick T. Reilly is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Cell growth & Chromatin. The author has an hindex of 17, co-authored 27 publications receiving 1429 citations. Previous affiliations of Patrick T. Reilly include University Health Network & State University of New York System.
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Journal ArticleDOI
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
Kathrin Zaugg,Yao Yi,Patrick T. Reilly,Karuppiah Kannan,Reza Kiarash,Jacqueline M. Mason,Ping Huang,Suzanne K. Sawyer,Benjamin J. Fuerth,Brandon Faubert,Tuula Kalliomaki,Tuula Kalliomaki,Tuula Kalliomaki,Andrew E. H. Elia,Xunyi Luo,Vincent Nadeem,David Bungard,Sireesha Yalavarthi,Joseph D. Growney,Joseph D. Growney,Joseph D. Growney,Andrew Wakeham,Yasmin Moolani,Jennifer Silvester,Annick You Ten,Walbert Bakker,Katsuya Tsuchihara,Shelley L. Berger,Shelley L. Berger,Shelley L. Berger,Richard P. Hill,Richard P. Hill,Richard P. Hill,Russell G. Jones,Ming Tsao,Murray O. Robinson,Craig B. Thompson,Craig B. Thompson,Guohua Pan,Tak W. Mak,Tak W. Mak +40 more
TL;DR: It is reported that carnitine palmitoyltransferase 1C (CPT1C), a brain-specific metabolic enzyme, may participate in metabolic transformation and may be a new therapeutic target for the treatment of hypoxic tumors.
Journal ArticleDOI
ANP32E is a histone chaperone that removes H2A.Z from chromatin
Arnaud Obri,Khalid Ouararhni,Christophe Papin,Marie Laure Diebold,Kiran Padmanabhan,Martin Marek,Isabelle Stoll,Ludovic Roy,Patrick T. Reilly,Tak W. Mak,Stefan Dimitrov,Christophe Romier,Ali Hamiche +12 more
TL;DR: It is shown that ANP32E is a member of the presumed H2A.Z histone-exchange complex p400/TIP60, and the crystal structure of the complex formed between the ANP 32E-ZID and the H2 a.Z/H2B dimer and biochemical data support an underlying molecular mechanism for H2 A.Z deposition and removal from chromatin.
Journal ArticleDOI
Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells.
TL;DR: It is proposed that the role of HCF-1 in cell proliferation is to regulate gene transcription by associating with a multiplicity of DNA-bound transcription factors through its VP16 interaction domain.
Journal ArticleDOI
Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay
David R. McIlwain,Qun Pan,Patrick T. Reilly,Andrew J. Elia,Susan McCracken,Andrew Wakeham,Annick Itie-Youten,Benjamin J. Blencowe,Tak W. Mak +8 more
TL;DR: A critical role for Smg1 in early mouse development is demonstrated and the loss of this NMD factor is linked to major and widespread changes in the mammalian transcriptome.
Journal ArticleDOI
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
Michael R. Bowl,Michelle Simon,Neil J. Ingham,Neil J. Ingham,Simon Greenaway,Luis Santos,Heather Cater,Sarah Taylor,Jeremy Mason,Natalja Kurbatova,Selina Pearson,Lynette Bower,Dave Clary,Hamid Meziane,Patrick T. Reilly,Osamu Minowa,Lois Kelsey,Lois Kelsey,Glauco P. Tocchini-Valentini,Xiang Gao,Allan Bradley,William C. Skarnes,Mark W. Moore,Arthur L. Beaudet,Monica J. Justice,John R. Seavitt,Mary E. Dickinson,Wolfgang Wurst,Martin Hrabé de Angelis,Yann Herault,Shigeharu Wakana,Lauryl M. J. Nutter,Lauryl M. J. Nutter,Ann M. Flenniken,Ann M. Flenniken,Colin McKerlie,Colin McKerlie,Stephen A. Murray,Karen L. Svenson,Robert E. Braun,David B. West,Kevin C K Lloyd,David J. Adams,Jacqui White,Natasha A. Karp,Paul Flicek,Damian Smedley,Terrence F. Meehan,Helen Parkinson,Lydia Teboul,Sara Wells,Karen P. Steel,Karen P. Steel,Ann-Marie Mallon,Steve D.M. Brown +54 more
TL;DR: A hearing loss screen in a cohort of 3006 mouse knockout strains reveals a large and unexplored genetic landscape involved with auditory function and identifies 52 new candidate genes for genetic hearing loss.