K
Khusru Asadullah
Researcher at Bayer HealthCare Pharmaceuticals
Publications - 89
Citations - 6132
Khusru Asadullah is an academic researcher from Bayer HealthCare Pharmaceuticals. The author has contributed to research in topics: Cytokine & Psoriasis. The author has an hindex of 35, co-authored 89 publications receiving 5903 citations. Previous affiliations of Khusru Asadullah include Humboldt State University & Charité.
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Journal ArticleDOI
Monocyte deactivation in septic patients: restoration by IFN-gamma treatment.
Wolf-Dietrich Döcke,Felix Randow,Uta Syrbe,Dietmar Krausch,Khusru Asadullah,Petre Reinke,Hans-Dieter Volk,Wolfgang J. Kox +7 more
TL;DR: Recovery of monocyte function resulted in clearance of sepsis in eight of nine patients and suggests that IFN-γ treatment in carefully selected septic patients is a novel therapeutic strategy worth pursuing.
Journal ArticleDOI
Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury.
Christian Woiciechowsky,Khusru Asadullah,D. Nestler,Beatrice Eberhardt,Cornelia Platzer,Cornelia Platzer,Britta Schöning,Frauke Glöckner,Wolfgang Lanksch,Hans-Dieter Volk,Wolf-Diatrich Döcke +10 more
TL;DR: It is found that in a rat model of acute brain injury, the βreceptor antagonist propranolol prevented the increase of interleukin-10 plasma levels and this may represent a common pathway for immunodepression induced by stress and injury.
Journal ArticleDOI
IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach.
Khusru Asadullah,Wolfram Sterry,K. Stephanek,D. Jasulaitis,M. Leupold,Heike Audring,Hans-Dieter Volk,W D Döcke +7 more
TL;DR: Investigations demonstrate the major importance of IL-10 in psoriasis and show thatIL-10 administration represents a new therapeutic approach, and is the first report on IL- 10 therapy for cutaneous disorders.
Journal ArticleDOI
Monocyte deactivation--rationale for a new therapeutic strategy in sepsis.
Hans-Dieter Volk,Petra Reinke,Dietmar Krausch,H. Zuckermann,Khusru Asadullah,Joachim M. Müller,W D Döcke,Wolfgang J. Kox +7 more
TL;DR: It is demonstrated that there is a biphasic immunologic response in sepsis: an initial hyperinflammatory phase is followed by a hypo-inflammmatory one, which is associated with immunodeficiency which is characterized by monocytic deactivation, which has been called “immunoparalysis”.
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Interleukin (IL)‐19, IL‐20 and IL‐24 are produced by and act on keratinocytes and are distinct from classical ILs
Stefanie Kunz,Kerstin Wolk,Ellen Witte,Katrin Witte,Wolf-Dietrich Doecke,Hans-Dieter Volk,Wolfram Sterry,Khusru Asadullah,Robert Sabat +8 more
TL;DR: The notion that IL‐19, IL‐20 and IL‐24 are distinct from classical ILs and constitute a separate subfamily of mediators within the IL‐10 family is supported.