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Wolf-Dietrich Doecke
Researcher at Bayer HealthCare Pharmaceuticals
Publications - 9
Citations - 1293
Wolf-Dietrich Doecke is an academic researcher from Bayer HealthCare Pharmaceuticals. The author has contributed to research in topics: Interleukin 20 & Transactivation. The author has an hindex of 6, co-authored 9 publications receiving 1214 citations. Previous affiliations of Wolf-Dietrich Doecke include Schering AG & Charité.
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Journal ArticleDOI
Immunologic and hemodynamic effects of "low-dose" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.
Didier Keh,Thomas Boehnke,Steffen Weber-Cartens,Christina Schulz,Olaf Ahlers,Sven Bercker,Hans-Dieter Volk,Wolf-Dietrich Doecke,Konrad J. Falke,Herwig Gerlach +9 more
TL;DR: Hydrocortisone therapy restored hemodynamic stability and differentially modulated the immunologic response to stress in a way of antiinflammation rather than immunosuppression.
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IL-22 Induces Lipopolysaccharide-Binding Protein in Hepatocytes: A Potential Systemic Role of IL-22 in Crohn’s Disease
Kerstin Wolk,Ellen Witte,Ute Hoffmann,Wolf-Dietrich Doecke,Stefanie Endesfelder,Khusru Asadullah,Wolfram Sterry,Hans-Dieter Volk,Bianca M. Wittig,Robert Sabat +9 more
TL;DR: It is demonstrated that IL-22, a cytokine that is mainly produced by activated Th1 and Th17 cells, was present in high quantities in the blood of CD patients in contrast to IFN-γ and IL-17 and found an up-regulation of LPS-binding protein (LBP) blood levels reaching concentrations known to neutralize LPS.
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Interleukin (IL)‐19, IL‐20 and IL‐24 are produced by and act on keratinocytes and are distinct from classical ILs
Stefanie Kunz,Kerstin Wolk,Ellen Witte,Katrin Witte,Wolf-Dietrich Doecke,Hans-Dieter Volk,Wolfram Sterry,Khusru Asadullah,Robert Sabat +8 more
TL;DR: The notion that IL‐19, IL‐20 and IL‐24 are distinct from classical ILs and constitute a separate subfamily of mediators within the IL‐10 family is supported.
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IL-19 Is a Component of the Pathogenetic IL-23/IL-17 Cascade in Psoriasis
Ellen Witte,Georgios Kokolakis,Katrin Witte,Sandra Philipp,Wolf-Dietrich Doecke,Nina Babel,Bianca M. Wittig,Katarzyna Warszawska,Agata Kurek,Magdalena Erdmann-Keding,Stefanie Kunz,Khusru Asadullah,Marshall E. Kadin,Hans-Dieter Volk,Wolfram Sterry,Kerstin Wolk,Robert Sabat +16 more
TL;DR: It is demonstrated that out of 30 individually quantified cytokines, IL-19 showed the strongest differential expression between psoriatic lesions and healthy skin and might be a biomarker for the activity of this axis in chronic inflammatory disorders.
Journal ArticleDOI
Standardized immune monitoring for the prediction of infections after cardiopulmonary bypass surgery in risk patients.
Jens-Christian Strohmeyer,Christian Blume,Christian Meisel,Wolf-Dietrich Doecke,Manfred Hummel,Conny Hoeflich,Kathi Thiele,Axel Unbehaun,Roland Hetzer,Hans-Dieter Volk +9 more
TL;DR: The diagnostic value of a standardized immune monitoring program based on recent advances in flow cytometry (exact quantification of surface‐marker expression) and cytokine determination (semiautomatic systems) is studied.