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Kiara J. Munir
Researcher at Brigham and Women's Hospital
Publications - 3
Citations - 793
Kiara J. Munir is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Exome & Cancer. The author has an hindex of 3, co-authored 3 publications receiving 621 citations.
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Journal ArticleDOI
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations
Raphael Bueno,Eric Stawiski,Leonard D. Goldstein,Steffen Durinck,Assunta De Rienzo,Zora Modrusan,Florian Gnad,Thong T. Nguyen,Bijay S. Jaiswal,Lucian R. Chirieac,Daniele Sciaranghella,Nhien Dao,Corinne E. Gustafson,Kiara J. Munir,Jason A. Hackney,Amitabha Chaudhuri,Ravi Gupta,Joseph Guillory,Karen Toy,Connie Ha,Ying-Jiun Chen,Jeremy Stinson,Subhra Chaudhuri,Na Zhang,Thomas D. Wu,David J. Sugarbaker,Frederic J. de Sauvage,William G. Richards,Somasekar Seshagiri +28 more
TL;DR: Recurrent gene fusions and splice alterations to be frequent mechanisms for inactivation of NF2, BAP1 and SETD2 are found and alterations in Hippo, mTOR, histone methylation, RNA helicase and p53 signaling pathways in MPMs are identified.
Journal ArticleDOI
Identification of Recurrent FGFR3–TACC3 Fusion Oncogenes from Lung Adenocarcinoma
Marzia Capelletti,Michael E. Dodge,Dalia Ercan,Peter S. Hammerman,Seung-Il Park,Jhingook Kim,Hidefumi Sasaki,David M. Jablons,Doron Lipson,Lauren Young,Phil Stephens,Vincent A. Miller,Neal I. Lindeman,Kiara J. Munir,William G. Richards,Pasi A. Jänne +15 more
TL;DR: FGFR3–TACC3 rearrangements occur in a subset of patients with lung adenocarcinoma, which should be considered for clinical trials featuring FGFR inhibitors.
Journal ArticleDOI
Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma.
Assunta De Rienzo,Michael A. Archer,Beow Y. Yeap,Nhien Dao,Daniele Sciaranghella,Antonios C. Sideris,Yifan Zheng,Alexander G. Holman,Yaoyu E. Wang,Paola Dal Cin,Jonathan A. Fletcher,Renee Rubio,Larry Croft,John Quackenbush,Peter E. Sugarbaker,Kiara J. Munir,Jesse R. Battilana,Corinne E. Gustafson,Lucian R. Chirieac,Soo Meng Ching,James R. Wong,Liang Chung Tay,Stephen Rudd,Robert Hercus,David J. Sugarbaker,William G. Richards,Raphael Bueno +26 more
TL;DR: Diverse mechanisms highly related to gender and histology appear to driveMalignant pleural mesothelioma, an aggressive cancer that occurs more frequently in men, but is associated with longer survival in women, are identified.