K
Kiel Iwanik
Researcher at Foundation Medicine
Publications - 3
Citations - 2177
Kiel Iwanik is an academic researcher from Foundation Medicine. The author has contributed to research in topics: genomic DNA & Gene expression profiling. The author has an hindex of 3, co-authored 3 publications receiving 1755 citations.
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Journal ArticleDOI
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing
Garrett M. Frampton,Alex Fichtenholtz,Geoff Otto,Kai Wang,Sean R. Downing,Jie He,Michael Schnall-Levin,Jared White,Eric M. Sanford,Peter An,James Sun,Frank Juhn,Kristina W. Brennan,Kiel Iwanik,Ashley Maillet,Jamie Buell,Emily White,Mandy Zhao,Sohail Balasubramanian,Selmira Terzic,Tina Richards,Vera Banning,Lazaro Garcia,Kristen Mahoney,Zac Zwirko,Amy Donahue,Himisha Beltran,Himisha Beltran,Juan Miguel Mosquera,Juan Miguel Mosquera,Mark A. Rubin,Mark A. Rubin,Snjezana Dogan,Cyrus V. Hedvat,Michael F. Berger,Lajos Pusztai,Matthias Lechner,Chris Boshoff,Mirna Jarosz,Christine Vietz,Alexander N. Parker,Vincent A. Miller,Jeffrey S. Ross,Jeffrey S. Ross,John Curran,Maureen T. Cronin,Philip J. Stephens,Doron Lipson,Roman Yelensky +48 more
TL;DR: A test based on massively parallel DNA sequencing to characterize base substitutions, short insertions and deletions (indels), copy number alterations and selected fusions across 287 cancer-related genes from routine formalin-fixed and paraffin-embedded (FFPE) clinical specimens is described.
Journal ArticleDOI
Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting
Jie He,Omar Abdel-Wahab,Michelle Nahas,Kai Wang,Raajit K. Rampal,Andrew M. Intlekofer,Jay Patel,Andrei V. Krivstov,Garrett M. Frampton,Lauren Young,Shan Zhong,Mark Bailey,Jared White,Steven Roels,Jason Deffenbaugh,Alex Fichtenholtz,Tim Brennan,Margaret Rosenzweig,Kimberly Pelak,Kristina M. Knapp,Kristina W. Brennan,Amy Donahue,Geneva Young,Lazaro Garcia,Selmira T. Beckstrom,Mandy Zhao,Emily White,Vera Banning,Jamie Buell,Kiel Iwanik,Jeffrey S. Ross,Deborah Morosini,Anas Younes,Alan M. Hanash,Elisabeth Paietta,Kathryn G. Roberts,Charles G. Mullighan,Ahmet Dogan,Scott A. Armstrong,Tariq I. Mughal,Tariq I. Mughal,Jo Anne Vergilio,Elaine LaBrecque,Rachel L. Erlich,Christine Vietz,Roman Yelensky,Philip J. Stephens,Vincent A. Miller,Marcel R.M. van den Brink,Geoff Otto,Doron Lipson,Ross L. Levine +51 more
TL;DR: A novel next-generation sequencing-based assay to identify all classes of genomic alterations using archived formalin-fixed paraffin-embedded blood and bone marrow samples with high accuracy in a clinically relevant time frame is developed, which increases the ability to identify clinically relevant genomic alterations with therapeutic relevance.
Journal ArticleDOI
Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Site: New Routes to Targeted Therapies.
Jeffrey S. Ross,Jeffrey S. Ross,Kai Wang,Geoff Otto,Emily White,Kiel Iwanik,Gary A. Palmer,Roman Yelensky,Doron Lipson,Juliann Chmielecki,Rachel L. Erlich,Andrew Rankin,Siraj M. Ali,Julia A. Elvin,Deborah Morosini,Vincent A. Miller,Philip J. Stephens +16 more
TL;DR: Almost all CUP samples harbored at least 1 clinically relevant GA with potential to influence and personalize therapy and the ACUP tumors were more frequently driven by GAs in the highly druggable RTK/Ras/mitogen-activated protein kinase (MAPK) signaling pathway than the non-ACUP tumors.