F
Frank Juhn
Researcher at Foundation Medicine
Publications - 13
Citations - 3791
Frank Juhn is an academic researcher from Foundation Medicine. The author has contributed to research in topics: Shewanella & Shewanella oneidensis. The author has an hindex of 8, co-authored 13 publications receiving 3286 citations. Previous affiliations of Frank Juhn include Broad Institute & Boston University.
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Journal ArticleDOI
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing
Garrett M. Frampton,Alex Fichtenholtz,Geoff Otto,Kai Wang,Sean R. Downing,Jie He,Michael Schnall-Levin,Jared White,Eric M. Sanford,Peter An,James Sun,Frank Juhn,Kristina W. Brennan,Kiel Iwanik,Ashley Maillet,Jamie Buell,Emily White,Mandy Zhao,Sohail Balasubramanian,Selmira Terzic,Tina Richards,Vera Banning,Lazaro Garcia,Kristen Mahoney,Zac Zwirko,Amy Donahue,Himisha Beltran,Himisha Beltran,Juan Miguel Mosquera,Juan Miguel Mosquera,Mark A. Rubin,Mark A. Rubin,Snjezana Dogan,Cyrus V. Hedvat,Michael F. Berger,Lajos Pusztai,Matthias Lechner,Chris Boshoff,Mirna Jarosz,Christine Vietz,Alexander N. Parker,Vincent A. Miller,Jeffrey S. Ross,Jeffrey S. Ross,John Curran,Maureen T. Cronin,Philip J. Stephens,Doron Lipson,Roman Yelensky +48 more
TL;DR: A test based on massively parallel DNA sequencing to characterize base substitutions, short insertions and deletions (indels), copy number alterations and selected fusions across 287 cancer-related genes from routine formalin-fixed and paraffin-embedded (FFPE) clinical specimens is described.
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Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
Doron Lipson,Marzia Capelletti,Roman Yelensky,Geoff Otto,Alexander N. Parker,Mirna Jarosz,John Curran,Sohail Balasubramanian,Troy Bloom,Kristina W. Brennan,Amy Donahue,Sean R. Downing,Garrett M. Frampton,Lazaro Garcia,Frank Juhn,Kathy C Mitchell,Emily White,Jared White,Zac Zwirko,Tamar Peretz,Hovav Nechushtan,Lior Soussan-Gutman,Jhingook Kim,Hidefumi Sasaki,Hyeong Ryul Kim,Seung-Il Park,Dalia Ercan,Christine E. Sheehan,Jeffrey S. Ross,Jeffrey S. Ross,Maureen T. Cronin,Pasi A. Jänne,Philip J. Stephens +32 more
TL;DR: Applying a next-generation sequencing assay targeting 145 cancer-relevant genes in 40 colorectal cancer and 24 non–small cell lung cancer formalin-fixed paraffin-embedded tissue specimens identified at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorective cancer sample and KIF5B-RET in a lung adenocarcinoma.
Journal ArticleDOI
A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries
Sheila Fisher,Andrew Barry,Justin Abreu,Brian Minie,Jillian Nolan,Toni Delorey,Geneva Young,Timothy Fennell,Alexander Allen,Lauren Ambrogio,Aaron M. Berlin,Brendan Blumenstiel,Kristian Cibulskis,Dennis C. Friedrich,Ryan Johnson,Frank Juhn,Brian Reilly,Ramy Shammas,John Stalker,Sean M. Sykes,Jon Thompson,John Jarlath Walsh,Andrew Zimmer,Zac Zwirko,Zac Zwirko,Stacey Gabriel,Robert Nicol,Chad Nusbaum +27 more
TL;DR: An automated, highly scalable method for carrying out the Solution Hybrid Selection capture approach that provides a dramatic increase in scale and throughput of sequence-ready libraries produced is presented.
Journal ArticleDOI
Many Microbe Microarrays Database: Uniformly Normalized Affymetrix Compendia with Structured Experimental Metadata
Jeremiah J. Faith,Michael E. Driscoll,Vincent A. Fusaro,Elissa J. Cosgrove,Boris Hayete,Frank Juhn,Stephen J. Schneider,Timothy S. Gardner +7 more
TL;DR: The experimental condition metadata in M3D is human curated with each chemical and growth attribute stored as a structured and computable set of experimental features with consistent naming conventions and units.
Journal ArticleDOI
A scalable, fully automated process for construction of sequence-ready barcoded libraries for 454
Niall J. Lennon,Robert E. Lintner,Scott Anderson,Pablo Alvarez,Andrew Barry,William Brockman,Riza M. Daza,Rachel L. Erlich,Georgia Giannoukos,Lisa Green,Andrew Hollinger,Cindi A. Hoover,David B. Jaffe,Frank Juhn,Danielle McCarthy,Danielle Perrin,Karen Ponchner,Taryn L Powers,Kamran Rizzolo,Dana Robbins,Elizabeth M. Ryan,Carsten Russ,Todd Sparrow,John Stalker,Scott Steelman,Michael Weiand,Andrew Zimmer,Matthew R. Henn,Chad Nusbaum,Robert Nicol +29 more
TL;DR: An automated, high throughput library construction process for 454 technology, where one technician can create 96 sequence-ready 454 libraries in 2 days, a dramatic improvement over the standard method.