K
Kikuko Hotta
Researcher at Osaka Ohtani University
Publications - 77
Citations - 20366
Kikuko Hotta is an academic researcher from Osaka Ohtani University. The author has contributed to research in topics: Single-nucleotide polymorphism & Nonalcoholic fatty liver disease. The author has an hindex of 36, co-authored 76 publications receiving 19606 citations. Previous affiliations of Kikuko Hotta include Kyoto University & Osaka University.
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Journal ArticleDOI
Secretogranin II binds to secretogranin III and forms secretory granules with orexin, neuropeptide Y, and POMC.
TL;DR: It is suggested that SCG2, as well as SCG3, may be a potential regulator of food intake based on its capacity to accumulate appetite-related hormones into secretory granules and be unresponsive to chronic body weight changes.
Journal ArticleDOI
Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population.
Kikuko Hotta,Michihiro Nakamura,Takahiro Nakamura,Tomoaki Matsuo,Yoshio Nakata,Seika Kamohara,Nobuyuki Miyatake,Kazuaki Kotani,Ryoya Komatsu,Naoto Itoh,Ikuo Mineo,Jun Wada,Masato Yoneda,Atsushi Nakajima,Tohru Funahashi,Shigeru Miyazaki,Katsuto Tokunaga,Manabu Kawamoto,Hiroaki Masuzaki,Takato Ueno,Kazuyuki Hamaguchi,Kiyoji Tanaka,Kentaro Yamada,Toshiaki Hanafusa,Shinichi Oikawa,Hironobu Yoshimatsu,Kazuwa Nakao,Toshiie Sakata,Yuji Matsuzawa,Yusuke Nakamura,Naoyuki Kamatani +30 more
TL;DR: The data suggest that some SNPs, which were identified in genome-wide studies in the Caucasians, also confer susceptibility to fat distribution in the recruited Japanese subjects.
Journal ArticleDOI
Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity.
Atsushi Tanabe,Takahiro Yanagiya,Aritoshi Iida,Susumu Saito,Akihiro Sekine,Atsushi Takahashi,Takahiro Nakamura,Tatsuhiko Tsunoda,Seika Kamohara,Yoshio Nakata,Kazuaki Kotani,Ryoya Komatsu,Naoto Itoh,Ikuo Mineo,Jun Wada,Tohru Funahashi,Shigeru Miyazaki,Katsuto Tokunaga,Kazuyuki Hamaguchi,Tatsuo Shimada,Kiyoji Tanaka,Kentaro Yamada,Toshiaki Hanafusa,Shinichi Oikawa,Hironobu Yoshimatsu,Toshiie Sakata,Yuji Matsuzawa,Naoyuki Kamatani,Yusuke Nakamura,Kikuko Hotta +29 more
TL;DR: Twelve SNPs in the SCG3 gene including rs3764220 were in almost complete linkage disequilibrium and significantly associated with an obesity phenotype and may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion.
Journal ArticleDOI
Genetic variations in the CYP17A1 and NT5C2 genes are associated with a reduction in visceral and subcutaneous fat areas in Japanese women
Kikuko Hotta,Aya Kitamoto,Takuya Kitamoto,Seiho Mizusawa,Hajime Teranishi,Tomoaki Matsuo,Yoshio Nakata,Hideyuki Hyogo,Hidenori Ochi,Takahiro Nakamura,Seika Kamohara,Nobuyuki Miyatake,Kazuaki Kotani,Ryoya Komatsu,Naoto Itoh,Ikuo Mineo,Jun Wada,Masato Yoneda,Atsushi Nakajima,Tohru Funahashi,Shigeru Miyazaki,Katsuto Tokunaga,Hiroaki Masuzaki,Takato Ueno,Kazuaki Chayama,Kazuyuki Hamaguchi,Kentaro Yamada,Toshiaki Hanafusa,Shinichi Oikawa,Hironobu Yoshimatsu,Toshiie Sakata,Kiyoji Tanaka,Yuji Matsuzawa,Kazuwa Nakao,Akihiro Sekine +34 more
TL;DR: The results suggest that polymorphisms in the CYP17A1 and NT5C2 genes influence a reduction in both visceral and subcutaneous fat mass in Japanese women.
Journal ArticleDOI
Characteristics of cardiac hypertrophy in the juvenile visceral steatosis mouse with systemic carnitine deficiency
Masamichi Kuwajima,Kang Mo Lu,Masako Sei,Akira Ono,Miyuki Hayashi,Kirie Ishiguro,Kiyokazu Ozaki,Kikuko Hotta,Kohei Okita,Takashi Murakami,Jun-ichiro Miyagawa,Isao Narama,Hiroko Nikaido,Jun Ichiro Hayakawa,H. Nakajima,Mitsuyoshi Namba,T. Hanafusa,Yuji Matsuzawa,Kenji Shima +18 more
TL;DR: The cardiac enlargement observed in this animal model could be accounted for by a proportional increase in the myocyte diameter in the ventricles and septum, accompanied by an increase in mitochondria, and this cellular growth is associated with decreases in the levels of ATP and ADP, and adenylate energy charge.