K
Kikuko Hotta
Researcher at Osaka Ohtani University
Publications - 77
Citations - 20366
Kikuko Hotta is an academic researcher from Osaka Ohtani University. The author has contributed to research in topics: Single-nucleotide polymorphism & Nonalcoholic fatty liver disease. The author has an hindex of 36, co-authored 76 publications receiving 19606 citations. Previous affiliations of Kikuko Hotta include Kyoto University & Osaka University.
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Journal ArticleDOI
Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.
Takuya Kitamoto,Aya Kitamoto,Masato Yoneda,Hideyuki Hyogo,Hidenori Ochi,Takahiro Nakamura,Hajime Teranishi,Seiho Mizusawa,Takato Ueno,Kazuaki Chayama,Atsushi Nakajima,Kazuwa Nakao,Akihiro Sekine,Kikuko Hotta +13 more
TL;DR: Polymorphisms in the SAMM50 and PARVB genes in addition to those in the PNPLA3 gene were observed to be associated with the development and progression of NAFLD.
Journal ArticleDOI
Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease
Kikuko Hotta,Masato Yoneda,Hideyuki Hyogo,Hidenori Ochi,Seiho Mizusawa,Takato Ueno,Kazuaki Chayama,Atsushi Nakajima,Kazuwa Nakao,Akihiro Sekine +9 more
TL;DR: It is found that in the Japanese population, individuals harboring the G-allele of rs738409 were susceptible to NAFLD, and that the SNP was associated with plasma levels of ALT, AST, and ferritin, and the histological fibrosis stage.
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Enhancement of the Aquaporin Adipose Gene Expression by a Peroxisome Proliferator-activated Receptor γ
Ken Kishida,Iichiro Shimomura,Hitoshi Nishizawa,Norikazu Maeda,Hiroshi Kuriyama,Hidehiko Kondo,Morihiro Matsuda,Hiroyuki Nagaretani,Noriyuki Ouchi,Kikuko Hotta,Shinji Kihara,Takashi Kadowaki,Tohru Funahashi,Yuji Matsuzawa +13 more
TL;DR: The current study demonstrates that aquaporin adipose (AQPap), an adipose-specific glycerol channel, is a target gene of peroxisome proliferator-activated receptor (PPAR) γ through the binding of PPARγ-retinoid X receptor complex to the PPRE region in its promoter.
Journal ArticleDOI
Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population
Kikuko Hotta,Michihiro Nakamura,Takahiro Nakamura,Tomoaki Matsuo,Yoshio Nakata,Seika Kamohara,Nobuyuki Miyatake,Kazuaki Kotani,Ryoya Komatsu,Naoto Itoh,Ikuo Mineo,Jun Wada,Hiroaki Masuzaki,Masato Yoneda,Atsushi Nakajima,Tohru Funahashi,Shigeru Miyazaki,Katsuto Tokunaga,Manabu Kawamoto,Takato Ueno,Kazuyuki Hamaguchi,Kiyoji Tanaka,Kentaro Yamada,Toshiaki Hanafusa,Shinichi Oikawa,Hironobu Yoshimatsu,Kazuwa Nakao,Toshiie Sakata,Yuji Matsuzawa,Naoyuki Kamatani,Yusuke Nakamura +30 more
TL;DR: Genotyped 27 single-nucleotide polymorphisms in 14 genes from obese subjects and suggest that some SNPs identified by genome-wide association studies in the Caucasians also confer susceptibility to obesity in Japanese subjects.
Journal ArticleDOI
Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity.
Kikuko Hotta,Tohru Funahashi,Yuko Matsukawa,Masahiko Takahashi,Hitoshi Nishizawa,Ken Kishida,Morihiro Matsuda,Hiroshi Kuriyama,Shinji Kihara,Tadashi Nakamura,Yoshihiro Tochino,Noni L. Bodkin,Barbara C. Hansen,Yuji Matsuzawa +13 more
TL;DR: Induction of galectin-12 expression by the thiazolidinedione, troglitazone, was paralleled by an increase in the number of apoptotic cells in adipose tissue and results suggest that galectIn-12, an adipose-expressed galECTin-like molecule, may participate in the apoptosis of adipocytes.