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Naoyuki Kamatani
Researcher at University of Michigan
Publications - 553
Citations - 34676
Naoyuki Kamatani is an academic researcher from University of Michigan. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 91, co-authored 548 publications receiving 32240 citations. Previous affiliations of Naoyuki Kamatani include Mitsubishi Research Institute.
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Journal ArticleDOI
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
Shigeru Kotake,Nobuyuki Udagawa,Naoyuki Takahashi,Kenichiro Matsuzaki,Kanami Itoh,Shigeru Ishiyama,Seiji Saito,Kazuhiko Inoue,Naoyuki Kamatani,Matthew T. Gillespie,T. John Martin,Tatsuo Suda +11 more
TL;DR: It is suggested that IL-17 first acts on osteoblasts, which stimulates both COX-2-dependent PGE2 synthesis and ODF gene expression, which in turn induce differentiation of osteoclast progenitors into mature osteoclasts, and that IL -17 is a crucial cytokine for osteoclastic bone resorption in RA patients.
Journal ArticleDOI
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
Akihiro Fujimoto,Yasushi Totoki,Tetsuo Abe,Keith A. Boroevich,Fumie Hosoda,Ha Hai Nguyen,Masayuki Aoki,Naoya Hosono,Michiaki Kubo,Fuyuki Miya,Yasuhito Arai,Hiroyuki Takahashi,Takuya Shirakihara,Masao Nagasaki,Tetsuo Shibuya,Kaoru Nakano,Kumiko Watanabe-Makino,Hiroko Tanaka,Hiromi Nakamura,Jun Kusuda,Hidenori Ojima,Kazuaki Shimada,Takuji Okusaka,Masaki Ueno,Yoshinobu Shigekawa,Yoshiiku Kawakami,Koji Arihiro,Hideki Ohdan,Kunihito Gotoh,Osamu Ishikawa,Shunichi Ariizumi,Masakazu Yamamoto,Terumasa Yamada,Kazuaki Chayama,Tomoo Kosuge,Hiroki Yamaue,Naoyuki Kamatani,Satoru Miyano,Hitoshi Nakagama,Yusuke Nakamura,Tatsuhiko Tsunoda,Tatsuhiro Shibata,Hidewaki Nakagawa +42 more
TL;DR: The whole-genome sequencing analysis of HCCs identified the influence of etiological background on somatic mutation patterns and subsequent carcinogenesis, as well as recurrent mutations in chromatin regulators in H CCs.
Journal ArticleDOI
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.
Kazuki Yasuda,Kazuaki Miyake,Yukio Horikawa,Hara Kazuo,Haruhiko Osawa,Hiroto Furuta,Yushi Hirota,Hiroyuki Mori,Anna Jonsson,Yoshifumi Sato,Kazuya Yamagata,Kazuya Yamagata,Yoshinori Hinokio,He-Yao Wang,Toshihito Tanahashi,Naoto Nakamura,Yoshitomo Oka,Naoko Iwasaki,Yasuhiko Iwamoto,Yuichiro Yamada,Yuichiro Yamada,Yutaka Seino,Yutaka Seino,Hiroshi Maegawa,Atsunori Kashiwagi,Jun Takeda,Eiichi Maeda,Hyoung Doo Shin,Young Min Cho,Kyong Soo Park,Hong Kyu Lee,Maggie C.Y. Ng,Ronald C.W. Ma,Wing-Yee So,Juliana C.N. Chan,Valeriya Lyssenko,Tiinamaija Tuomi,Peter M. Nilsson,Leif Groop,Leif Groop,Naoyuki Kamatani,Akihiro Sekine,Yusuke Nakamura,Ken Yamamoto,Yoshida Teruhiko,Katsushi Tokunaga,Mitsuo Itakura,Hideichi Makino,Kishio Nanjo,Takashi Kadowaki,Masato Kasuga +50 more
TL;DR: The data implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries as well as in two independent Japanese populations, and the risk allele of this polymorphism was associated with impairment of insulin secretion according to the homeostasis model assessment of β-cell function or the corrected insulin response.
Journal ArticleDOI
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
Hiroyuki Unoki,Atsushi Takahashi,Takahisa Kawaguchi,Kazuo Hara,Momoko Horikoshi,Gitte Andersen,Daniel P.K. Ng,Johan Holmkvist,Knut Borch-Johnsen,Knut Borch-Johnsen,Knut Borch-Johnsen,Torben Jørgensen,Annelli Sandbæk,Torsten Lauritzen,Torben Hansen,Siti Nurbaya,Tatsuhiko Tsunoda,Michiaki Kubo,Tetsuya Babazono,Hiroshi Hirose,Matsuhiko Hayashi,Yasuhiko Iwamoto,Atsunori Kashiwagi,Kohei Kaku,Ryuzo Kawamori,E. Shyong Tai,Oluf Pedersen,Oluf Pedersen,Naoyuki Kamatani,Takashi Kadowaki,Ryuichi Kikkawa,Yusuke Nakamura,Shiro Maeda +32 more
TL;DR: A genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 1 diabetes.
Journal ArticleDOI
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Anna Köttgen,Anna Köttgen,Eva Albrecht,Alexander Teumer,Veronique Vitart,Jan Krumsiek,Claudia Hundertmark,Giorgio Pistis,Daniela Ruggiero,Conall M. O'Seaghdha,Conall M. O'Seaghdha,Toomas Haller,Qiong Yang,Qiong Yang,Toshiko Tanaka,Andrew D. Johnson,Zoltán Kutalik,Zoltán Kutalik,Albert V. Smith,Julia Shi,Maksim Struchalin,Rita P. S. Middelberg,Morris J. Brown,Angelo L. Gaffo,Nicola Pirastu,Guo Li,Caroline Hayward,Tatijana Zemunik,Jennifer E. Huffman,Loic Yengo,Jing Hua Zhao,Ayse Demirkan,Mary F. Feitosa,Xuan Liu,Giovanni Malerba,Lorna M. Lopez,Pim van der Harst,Xinzhong Li,Marcus E. Kleber,Andrew A. Hicks,Ilja M. Nolte,Åsa Johansson,Federico Murgia,Sarah H. Wild,Stephan J. L. Bakker,John F. Peden,Abbas Dehghan,Maristella Steri,Albert Tenesa,Vasiliki Lagou,Perttu Salo,Massimo Mangino,Lynda M. Rose,Terho Lehtimäki,Owen M. Woodward,Yukinori Okada,Adrienne Tin,Christian Müller,Christopher Oldmeadow,Margus Putku,Darina Czamara,Peter Kraft,Laura Frogheri,Gian Andri Thun,Gian Andri Thun,Anne Grotevendt,Gauti Kjartan Gislason,Tamara B. Harris,Lenore J. Launer,Patrick F. McArdle,Alan R. Shuldiner,Eric Boerwinkle,Josef Coresh,Helena Schmidt,Michael Schallert,Nicholas G. Martin,Grant W. Montgomery,Michiaki Kubo,Yusuke Nakamura,Toshihiro Tanaka,Patricia B. Munroe,Nilesh J. Samani,Nilesh J. Samani,David R. Jacobs,Kiang Liu,Pio D'Adamo,Sheila Ulivi,Jerome I. Rotter,Bruce M. Psaty,Bruce M. Psaty,Peter Vollenweider,Gérard Waeber,Susan Campbell,Olivier Devuyst,Pau Navarro,Ivana Kolcic,Nicholas D. Hastie,Beverley Balkau,Philippe Froguel,Tõnu Esko,Andres Salumets,Kay-Tee Khaw,Claudia Langenberg,Nicholas J. Wareham,Aaron Isaacs,Aldi Kraja,Qunyuan Zhang,Qunyuan Zhang,Philipp S. Wild,Rodney J. Scott,Elizabeth G. Holliday,Elin Org,Margus Viigimaa,Stefania Bandinelli,Jeffrey Metter,Antonio Lupo,Elisabetta Trabetti,Rossella Sorice,Angela Döring,Eva Lattka,Konstantin Strauch,Fabian J. Theis,Melanie Waldenberger,H.-Erich Wichmann,Gail Davies,Alan J. Gow,Marcel Bruinenberg,Ronald P. Stolk,Jaspal S. Kooner,Jaspal S. Kooner,Weihua Zhang,Weihua Zhang,Bernhard R. Winkelmann,Bernhard O. Boehm,Susanne Lucae,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Johannes H. Smit,Gary C. Curhan,Poorva Mudgal,Poorva Mudgal,Robert M. Plenge,Robert M. Plenge,Laura Portas,Ivana Persico,Mirna Kirin,James F. Wilson,Irene Mateo Leach,Wiek H. van Gilst,Anuj Goel,Halit Ongen,Albert Hofman,Fernando Rivadeneira,André G. Uitterlinden,Medea Imboden,Medea Imboden,Arnold von Eckardstein,Francesco Cucca,Ramaiah Nagaraja,Maria Grazia Piras,Matthias Nauck,Claudia Schurmann,Kathrin Budde,Florian Ernst,Susan M. Farrington,Evropi Theodoratou,Inga Prokopenko,Michael Stumvoll,A. Jula,Markus Perola,Markus Perola,Markus Perola,Veikko Salomaa,So-Youn Shin,Tim D. Spector,Cinzia Sala,Paul M. Ridker,Mika Kähönen,Jorma Viikari,Christian Hengstenberg,Christopher P. Nelson,Christopher P. Nelson,James F. Meschia,Mike A. Nalls,Pankaj Sharma,Andrew B. Singleton,Naoyuki Kamatani,Tanja Zeller,Michel Burnier,John Attia,Maris Laan,Norman Klopp,Hans L. Hillege,Stefan Kloiber,Hyon K. Choi,Hyon K. Choi,Mario Pirastu,Silvia Tore,Nicole Probst-Hensch,Nicole Probst-Hensch,Henry Völzke,Vilmundur Gudnason,Afshin Parsa,Reinhold Schmidt,John Whitfield,Myriam Fornage,Paolo Gasparini,David S. Siscovick,Ozren Polasek,Harry Campbell,Igor Rudan,Igor Rudan,Nabila Bouatia-Naji,Andres Metspalu,Ruth J. F. Loos,Cornelia M. van Duijn,Ingrid B. Borecki,Luigi Ferrucci,Giovanni Gambaro,Ian J. Deary,Bruce H. R. Wolffenbuttel,John C. Chambers,John C. Chambers,Winfried März,Winfried März,Peter P. Pramstaller,Harold Snieder,Ulf Gyllensten,Alan F. Wright,Gerjan Navis,Hugh Watkins,Jacqueline C.M. Witteman,Serena Sanna,Sabine Schipf,Malcolm G. Dunlop,Anke Tönjes,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Nicole Soranzo,Daniela Toniolo,Daniel I. Chasman,Olli T. Raitakari,W. H. Linda Kao,Marina Ciullo,Caroline S. Fox,Caroline S. Fox,Mark J. Caulfield,Murielle Bochud,Christian Gieger +250 more
TL;DR: New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.