K
Kim Burns
Researcher at University of Lausanne
Publications - 10
Citations - 7287
Kim Burns is an academic researcher from University of Lausanne. The author has contributed to research in topics: Signal transduction & FADD. The author has an hindex of 10, co-authored 10 publications receiving 7095 citations.
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Journal ArticleDOI
Inhibition of death receptor signals by cellular FLIP
Martin Irmler,Margot Thome,Michael Hahne,Pascal Schneider,Kay Hofmann,Véronique Steiner,Jean-Luc Bodmer,Michael Schröter,Kim Burns,Chantal Mattmann,Donata Rimoldi,Lars E. French,Jürg Tschopp +12 more
TL;DR: The characterization of an inhibitor of apoptosis is reported, designated FLIP (for FLICE-inhibitory protein), which is predominantly expressed in muscle and lymphoid tissues and may be implicated in tissue homeostasis as an important regulator of apoptotic regulation.
Journal ArticleDOI
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
Margot Thome,Pascal Schneider,Kay Hofmann,Helmut Fickenscher,Edgar Meinl,Frank Neipel,Chantal Mattmann,Kim Burns,Jean Luc Bodmer,Michael Schröter,Carsten Scaffidi,Peter H. Krammer,Marcus E. Peter,Jürg Tschopp +13 more
TL;DR: A new family of viral inhibitors (v-FLIPs) which interfere with apoptosis signalled through death receptors3 and which are present in several γ-herpesviruses (including Kaposi's-sarcoma-associated human herpesvirus-8), as well as in the tumorigenic human molluscipoxvirus4.
Journal ArticleDOI
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.
Etienne Meylan,Kim Burns,Kay Hofmann,Vincent Blancheteau,Fabio Martinon,Michelle A. Kelliher,Jürg Tschopp +6 more
TL;DR: This work investigated the 'downstream' signaling events that regulate TLR3-dependent Trif-induced NF-κB activation and found that RIP1 mediates Trif -RIP1–inducedNF-κBs activation.
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TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB
Pascal Schneider,Margot Thome,Kim Burns,Jean-Luc Bodmer,Kay Hofmann,Takao Kataoka,Nils Holler,Jürg Tschopp +7 more
TL;DR: It is shown that TRAil-R1 can associate with TRAIL-R2, suggesting that TRAIL may signal through heteroreceptor signaling complexes, and can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP.
Journal ArticleDOI
The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways
Takao Kataoka,Ralph C. Budd,Ralph C. Budd,Nils Holler,Margot Thome,Fabio Martinon,Martin Irmler,Kim Burns,Michael Hahne,Norman J. Kennedy,M. Kovacsovics,J. Tschopp +11 more
TL;DR: Evidence is provided that FLIP is not simply an inhibitor of death-receptor-induced apoptosis but that it also mediates the activation of NF-kappaB and Erk by virtue of its capacity to recruit adaptor proteins involved in these signaling pathways.