K
Kimitoshi Nakamura
Researcher at Kumamoto University
Publications - 192
Citations - 5483
Kimitoshi Nakamura is an academic researcher from Kumamoto University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 29, co-authored 157 publications receiving 4649 citations. Previous affiliations of Kimitoshi Nakamura include University of Alberta & Canadian Institutes of Health Research.
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Journal ArticleDOI
Calreticulin: one protein, one gene, many functions.
TL;DR: Calreticulin is a highly versatile lectin-like chaperone, and it participates during the synthesis of a variety of molecules, including ion channels, surface receptors, integrins and transporters.
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Calreticulin Is Essential for Cardiac Development
Nasrin Mesaeli,Kimitoshi Nakamura,Elena Zvaritch,Peter Dickie,Ewa Dziak,Karl-Heinz Krause,Michal Opas,David H. MacLennan,Marek Michalak +8 more
TL;DR: It is shown that the calreticulin gene is highly activated in the cardiovascular system during the early stages of cardiac development, and plays a role in cardiac development as a component of the Ca2+/calcineurin/NF-AT/GATA-4 transcription pathway.
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Changes in Endoplasmic Reticulum Luminal Environment Affect Cell Sensitivity to Apoptosis
Kimitoshi Nakamura,Kimitoshi Nakamura,Ella Bossy-Wetzel,Kimberly Burns,Kimberly Burns,Marc P. Fadel,Mira D Lozyk,Ing Swie Goping,Michal Opas,R. Chris Bleackley,Douglas R. Green,Marek Michalak +11 more
TL;DR: Changes in the lumen of the ER amplify the release of cytochrome c from mitochondria, and increase caspase activity, during drug-induced apoptosis, which indicates that Apoptosis may depend on both the presence of external apoptosis-activating signals, and an internal factor represented by the ER.
Journal ArticleDOI
Functional specialization of calreticulin domains.
Kimitoshi Nakamura,Anna Zuppini,Serge Arnaudeau,Jeffery Lynch,Irfan Ahsan,Ryoko Krause,Sylvia Papp,Humbert De Smedt,Jan B. Parys,Werner Müller-Esterl,Daniel Pablo Lew,Karl-Heinz Krause,Nicolas Demaurex,Michal Opas,Marek Michalak +14 more
TL;DR: The results indicate that calreticulin may play a role in folding of the bradykinin receptor, which affects its ability to initiate InsP3-dependent Ca2+ release in calretiulin-deficient cells.
Journal ArticleDOI
Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin
Bin Gao,Raju Adhikari,Raju Adhikari,Mark Howarth,Mark Howarth,Kimitoshi Nakamura,Marielle C. Gold,Ann B. Hill,Rai Knee,Marek Michalak,Tim Elliott +10 more
TL;DR: MHC class I molecules expressed in a calreticulin-deficient cell line (K42) assembled with beta 2-microglobulin (beta2-m) normally, but their subsequent loading with optimal peptides was defective, resulting in impaired T cell recognition and reduced efficiency of peptide loading.