M
Marek Michalak
Researcher at University of Alberta
Publications - 263
Citations - 20549
Marek Michalak is an academic researcher from University of Alberta. The author has contributed to research in topics: Calreticulin & Endoplasmic reticulum. The author has an hindex of 73, co-authored 247 publications receiving 18963 citations. Previous affiliations of Marek Michalak include University of Exeter & Hubei University of Technology.
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Journal ArticleDOI
Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte
Shyra J. Gardai,Kathleen A. McPhillips,S. Courtney Frasch,William J. Janssen,Anna Starefeldt,Joanne E. Murphy-Ullrich,Donna L. Bratton,Per-Arne Oldenborg,Marek Michalak,Peter M. Henson +9 more
TL;DR: It is demonstrated here that calreticulin acts as a second general recognition ligand by binding and activating LDL-receptor-related protein (LRP) on the engulfing cell, which creates an environment where "don't eat me" signals are rendered inactive and "eat me" signalling signals congregate together and signal for removal.
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IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
Kyungho Lee,Witoon Tirasophon,Xiaohua Shen,Marek Michalak,Ron Prywes,Tetsuya Okada,Hiderou Yoshida,Kazutoshi Mori,Randal J. Kaufman +8 more
TL;DR: It is proposed that nuclear- localized IRE1alpha and cytoplasmic-localized ATF6 signaling pathways merge through regulation of XBP1 activity to induce downstream gene expression.
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Calreticulin: one protein, one gene, many functions.
TL;DR: Calreticulin is a highly versatile lectin-like chaperone, and it participates during the synthesis of a variety of molecules, including ion channels, surface receptors, integrins and transporters.
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Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum
TL;DR: Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule.
Journal ArticleDOI
Calreticulin Is Essential for Cardiac Development
Nasrin Mesaeli,Kimitoshi Nakamura,Elena Zvaritch,Peter Dickie,Ewa Dziak,Karl-Heinz Krause,Michal Opas,David H. MacLennan,Marek Michalak +8 more
TL;DR: It is shown that the calreticulin gene is highly activated in the cardiovascular system during the early stages of cardiac development, and plays a role in cardiac development as a component of the Ca2+/calcineurin/NF-AT/GATA-4 transcription pathway.