Privileged substructures are of potentially great importance in medicinal chemistry. These scaffolds are characterized by their ability to promiscuously bind to a multitude of receptors through a variety of favorable characteristics. This may include presentation of their substituents in a spatially defined manner and perhaps also the ability to directly bind to the receptor itself, as well as exhibiting promising characteristics to aid bioavailability of the overall molecule. It is believed that some privileged substructures achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns. As a result, these structures represent a promising means by which new lead compounds may be identified.

The combinatorial synthesis of bicyclic privileged structures or privileged substructures

The biochemistry and medical significance of the flavonoids.

Recent Developments in Ring Opening Polymerization of Lactones for Biomedical Applications

Polycaprolactone (PCL) is an important polymer due to its mechanical properties, miscibility with a large range of other polymers and biodegradability. Two main pathways to produce polycaprolactone have been described in the literature: the polycondensation of a hydroxycarboxylic acid: 6-hydroxyhexanoic acid, and the ring-opening polymerisation (ROP) of a lactone: e-caprolactone (e-CL). This critical review summarises the different conditions which have been described to synthesise PCL, and gives a broad overview of the different catalytic systems that were used (enzymatic, organic and metal catalyst systems). A surprising variety of catalytic systems have been studied, touching on virtually every section of the periodic table. A detailed list of reaction conditions and catalysts/initiators is given and reaction mechanisms are presented where known. Emphasis is put on the ROP pathway due to its prevalence in the literature and the superior polymer that is obtained. In addition, ineffective systems that have been tried to catalyse the production of PCL are included in the electronic supplementary information for completeness (141 references).

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Synthesis of polycaprolactone: a review

Biodegradable synthetic polymers: Preparation, functionalization and biomedical application

Studies of the dichloromethane extract of stems and the methanolic extract of fruits of Piper wightii Miq. resulted in the isolation of 12 compounds, all new for this species. They comprise a novel neolignan 1, a neolignan new as a natural product 2, a novel cyclohexane 5, two known neolignans 3 and 4, one known cyclohexane 6, and six known alkaloids 7, 8, 9, 10, 11 and 12.

Neolignans, cyclohexanes and alkaloids from Piper wightii

A benzoic acid ester from Uvaria narum

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Kirpal S. Bisht

Papers

Neolignans, cyclohexanes and alkaloids from Piper wightii

A benzoic acid ester from Uvaria narum

Benzofuranoid Neolignans from Piper wightii Miq..

Intramolecular inclusion in novel octaester cavitands.

Synthesis of glycolipid analogs via highly regioselective macrolactonization catalyzed by lipase