Kiryl Tsukerman

TL;DR: Analysis of this first sequenced endosymbiont genome from a filarial nematode provides insight into endosYmbionT evolution and additionally provides new potential targets for elimination of cutaneous and lymphatic human filarial disease.

TL;DR: In this paper, the 706,569-bp chromosome and four plasmids of the aster yellows phytoplasma strain witches' broom (AY-WB) were sequenced and compared to the onion yellows polygonal strain M (OY-M) genome, showing that the repeated DNAs are organized into large clusters of potential mobile units (PMUs), which contain tra5 insertion sequences (ISs) and genes for specialized sigma factors and membrane proteins.

TL;DR: Foster et al. as discussed by the authors presented the first sequenced endosymbiont genome from a filarial nematode, which provides new potential targets for elimination of cutaneous and lymphatic human filarial disease.

TL;DR: This comparative analysis revealed that the repeated DNAs are organized into large clusters of potential mobile units, which contain tra5 insertion sequences (ISs) and genes for specialized sigma factors and membrane proteins, so far, these PMUs appear to be unique to phytoplasmas.