K
Koichi Ishida
Researcher at Kao Corporation
Publications - 7
Citations - 268
Koichi Ishida is an academic researcher from Kao Corporation. The author has contributed to research in topics: Ceramide & Neprilysin. The author has an hindex of 6, co-authored 7 publications receiving 196 citations.
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Biological Mechanisms Underlying the Ultraviolet Radiation-Induced Formation of Skin Wrinkling and Sagging I: Reduced Skin Elasticity, Highly Associated with Enhanced Dermal Elastase Activity, Triggers Wrinkling and Sagging
Genji Imokawa,Koichi Ishida +1 more
TL;DR: Clinical studies using animal skin and human facial skin demonstrated that topical treatment with a specific inhibitor or an inhibitory extract of skin fibroblast-derived elastase distinctly attenuates UVB and sunlight-induced formation of wrinkling.
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Inhibitors of Intracellular Signaling Pathways that Lead to Stimulated Epidermal Pigmentation: Perspective of Anti-Pigmenting Agents
Genji Imokawa,Koichi Ishida +1 more
TL;DR: Extracts of the herbs Withania somnifera and Melia toosendan and the natural chemicals Withaferin A and Astaxanthin are new candidates for potent anti-pigmenting substances that avoid the risk of hypopigmentation.
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Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging II: over-expression of neprilysin plays an essential role.
TL;DR: Findings suggest that GM-CSF secreted by UVA-exposed keratinocytes as well as IL-6 secretedBy UVA -exposed dermal fibroblasts play important and additional roles in UVA/UVA-induced sagging and wrinkling by up-regulation of neprilysin and MMP-1, respectively, in dermal fibreblasts.
Journal ArticleDOI
Role of Ceramide in the Barrier Function of the Stratum Corneum, Implications for the Pathogenesis of Atopic Dermatitis
Genji Imokawa,Koichi Ishida +1 more
TL;DR: This review article explores the physiological and biochemical basis for the atopic dermatitis phenotype in terms of the barrier abnormality and associated factors such as ceramides and its metabolites in the following sequence.
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Treatment with Synthetic Pseudoceramide Improves Atopic Skin, Switching the Ceramide Profile to a Healthy Skin Phenotype.
TL;DR: Results indicate that the penetrated pCer contributes to shift the ceramide profile from an AD to a healthy skin phenotype, providing a deep insight into the pathogenesis of AD as a ceramide-deficient disease.