Treatment with Synthetic Pseudoceramide Improves Atopic Skin, Switching the Ceramide Profile to a Healthy Skin Phenotype.
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TLDR
Results indicate that the penetrated pCer contributes to shift the ceramide profile from an AD to a healthy skin phenotype, providing a deep insight into the pathogenesis of AD as a ceramide-deficient disease.About:
This article is published in Journal of Investigative Dermatology.The article was published on 2020-02-01 and is currently open access. It has received 18 citations till now. The article focuses on the topics: Ceramide & Stratum corneum.read more
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Skin lipids in health and disease: A review
Sophie Knox,Niamh M. O’Boyle +1 more
TL;DR: In this article, a review of the lipid composition of human skin is presented, and changes that have been found in skin lipid composition in different skin diseases, including different skin disorders and diseases.
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Update on the Pathogenesis and Therapy of Atopic Dermatitis.
TL;DR: In this paper, the main aspects of AD have been updated, with a focus on the pathogenetic and therapeutic aspects, and it is evident that a strong genetic predisposition, epidermal dysfunction, skin microbiome abnormalities, immune dysregulation, and the neuroimmune system are critical in AD development.
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The Pathogenic and Therapeutic Implications of Ceramide Abnormalities in Atopic Dermatitis.
TL;DR: Ceramide-dominant emollients have beneficial effects on skin barrier function; thus, they have been approved as an adjunctive barrier repair agent for atopic dermatitis.
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Cutting Edge of the Pathogenesis of Atopic Dermatitis: Sphingomyelin Deacylase, the Enzyme Involved in Its Ceramide Deficiency, Plays a Pivotal Role.
TL;DR: In this paper, sphingomyelin (SM) deacylase was found to be significantly increased in AD lesional epidermis as well as in the involved and uninvolved stratum corneum (SC) of patients with contact dermatitis or chronic eczema.
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Sphingomyelin Deacylase, the Enzyme Involved in the Pathogenesis of Atopic Dermatitis, Is Identical to the β-Subunit of Acid Ceramidase.
Yasuhiro Teranishi,Hiroshi Kuwahara,Masaru Ueda,Tadashi Takemura,Kusumoto Masanori,Keiji Nakamura,Jun Sakai,Toru Kimura,Yasuji Furutani,Makoto Kawashima,Genji Imokawa,Mari Nogami-Itoh +11 more
TL;DR: The purified SM deacylase was purified to homogeneity and characterized as an aCDase-degrading β-subunit that evokes the ceramide deficiency in AD skin, providing new insights into the essential role of SM deACYlase.
References
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PatentDOI
Measurement of protein using bicinchoninic acid
TL;DR: This new method maintains the high sensitivity and low protein-to-protein variation associated with the Lowry technique and demonstrates a greater tolerance of the bicinchoninate reagent toward such commonly encountered interferences as nonionic detergents and simple buffer salts.
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Decreased level of ceramides in stratum corneum of atopic dermatitis : an etiologic factor in atopic dry skin ?
TL;DR: Findings suggest that an insufficiency of ceramides in the stratum corneum is an etiologic factor in atopic dry skin.
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Ceramide and cholesterol composition of the skin of patients with atopic dermatitis.
TL;DR: The data confirm the view that impaired metabolism of ceramides may be the cause of dry skin and impaired barrier function in atopic dermatitis and suggest that a decrease in ceramide in the stratum corneum is involved in barrier impairment in atopy dermatitis skin.
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Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients
M. Janssens,Jeroen van Smeden,Gert S. Gooris,Wim Bras,Guiseppe Portale,Peter J. Caspers,Rob J. Vreeken,Thomas Hankemeier,Sanja Kezic,Ron Wolterbeek,A.P.M. Lavrijsen,Joke A. Bouwstra +11 more
TL;DR: It is demonstrated for the first time that changes in ceramide chain length and lipid organization are directly correlated with the skin barrier defects in nonlesional skin of AE patients and will provide a new therapeutic entry in therapy and prevention of AE.