K
Korbinian Löbmann
Researcher at University of Copenhagen
Publications - 123
Citations - 5051
Korbinian Löbmann is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Amorphous solid & Differential scanning calorimetry. The author has an hindex of 32, co-authored 116 publications receiving 3714 citations. Previous affiliations of Korbinian Löbmann include University of Otago.
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Emerging trends in the stabilization of amorphous drugs
Riikka Laitinen,Korbinian Löbmann,Korbinian Löbmann,Clare J. Strachan,Clare J. Strachan,Holger Grohganz,Thomas Rades,Thomas Rades +7 more
TL;DR: Formulation approaches such as the preparation of co-amorphous small-molecule mixtures and the use of mesoporous silicon and silica-based carriers are presented as potential means to increase the stability of amorphous pharmaceuticals.
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Recent advances in co-amorphous drug formulations
TL;DR: This study investigates co-amorphous formulations from the viewpoint of solid dispersions, describes their formation and mechanism of stabilization, study their impact on dissolution and in vivo performance and briefly outline the future potentials.
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Coamorphous drug systems: enhanced physical stability and dissolution rate of indomethacin and naproxen.
Korbinian Löbmann,Riikka Laitinen,Holger Grohganz,Keith C. Gordon,Clare J. Strachan,Thomas Rades +5 more
TL;DR: A coamorphous drug/drug combination between the two nonsteroidal anti-inflammatory drugs, naproxen and γ-indomethacin, was prepared and investigated and it was suggested that the two drugs formed a heterodimer.
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Amino acids as co-amorphous stabilizers for poorly water soluble drugs--Part 1: preparation, stability and dissolution enhancement.
Korbinian Löbmann,Holger Grohganz,Riikka Laitinen,Clare J. Strachan,Clare J. Strachan,Thomas Rades,Thomas Rades +6 more
TL;DR: Amino acids appear as promising excipients to solve challenges connected with the stability and dissolution of amorphous drugs.
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Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions.
Korbinian Löbmann,Clare J. Strachan,Holger Grohganz,Thomas Rades,Ossi Korhonen,Riikka Laitinen +5 more
TL;DR: Improved stability in co-amorphous SVS-GPZ mixtures was concluded that this was attributable to the molecular level mixing of SVS with GPZ upon milling, and GPZ is acting as an anti-plasticizer in these mixtures.