K
Kouji Kuramochi
Researcher at Tokyo University of Science
Publications - 79
Citations - 1115
Kouji Kuramochi is an academic researcher from Tokyo University of Science. The author has contributed to research in topics: Total synthesis & DNA polymerase. The author has an hindex of 17, co-authored 79 publications receiving 961 citations. Previous affiliations of Kouji Kuramochi include Kyoto Prefectural University.
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Journal ArticleDOI
Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets.
Daniel Arango,Kengo Morohashi,Alper Yilmaz,Kouji Kuramochi,Arti Parihar,Bledi Brahimaj,Erich Grotewold,Andrea I. Doseff +7 more
TL;DR: It is shown that, by inhibiting hnRNPA2 dimerization, apigenin affects the alternative splicing of key mRNAs, and provides a perspective on how dietary phytochemicals function and what distinguishes their action from pharmaceutical drugs.
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Oligonaphthofurans: Fan-Shaped and Three-Dimensional π-Compounds
Kentaro Nakanishi,Daisuke Fukatsu,Kazuto Takaishi,Taiki Tsuji,Keita Uenaka,Kouji Kuramochi,Takeo Kawabata,Kazunori Tsubaki +7 more
TL;DR: As the number of aromatic rings of the oligonaphthofurans increased, the peaks of the longest wavelength absorptions in the UV-vis spectra of these compounds steadily red-shifted, although the shapes of spectra were not sustained because of the decreasing molar absorption coefficients of their λ(max).
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Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
Yusuke Myobatake,Toshifumi Takeuchi,Kouji Kuramochi,Isoko Kuriyama,Tomomi Ishido,Ken Hirano,Fumio Sugawara,Hiromi Yoshida,Yoshiyuki Mizushina +8 more
TL;DR: The compounds suppressed cell proliferation and growth in five human cancer cell lines, but had no effect on the viability of normal human cell lines.
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Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B.
Kengo Morohashi,Hiroeki Sahara,Koichi Watashi,Kazuki Iwabata,Takashi Sunoki,Kouji Kuramochi,Kaori Takakusagi,Hiroki Miyashita,Noriyuki Sato,Atsushi Tanabe,Kunitada Shimotohno,Susumu Kobayashi,Kengo Sakaguchi,Fumio Sugawara +13 more
TL;DR: A chemical biology approach is shown that elucidates a novel mechanism underlying cellular and viral physiology of HCV replication and finds a cellular factor, CAHL, as CsA associated helicase-like protein, which would form trimer complex with CyPB and NS5B ofHCV.
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Exhaustive Syntheses of Naphthofluoresceins and Their Functions
Eriko Azuma,Naoko Nakamura,Kouji Kuramochi,Takahiro Sasamori,Norihiro Tokitoh,Ikuko Sagami,Kazunori Tsubaki +6 more
TL;DR: Naphthofluoresce in derivatives possessing the additional benzene units to one or both sides of fluorescein were exhaustively constructed through Friedel-Crafts type reactions between corresponding aroylbenzoic acids and dihydroxynaphthalenes.