K
Koumei Shirasuna
Researcher at Tokyo University of Agriculture
Publications - 150
Citations - 3769
Koumei Shirasuna is an academic researcher from Tokyo University of Agriculture. The author has contributed to research in topics: Corpus luteum & Luteal phase. The author has an hindex of 34, co-authored 139 publications receiving 3041 citations. Previous affiliations of Koumei Shirasuna include Japanese Foundation for Cancer Research & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Inflammasome Activation by Mitochondrial Oxidative Stress in Macrophages Leads to the Development of Angiotensin II–Induced Aortic Aneurysm
Fumitake Usui,Koumei Shirasuna,Hiroaki Kimura,Kazuki Tatsumi,Akira Kawashima,Tadayoshi Karasawa,Koichi Yoshimura,Hiroki Aoki,Hiroko Tsutsui,Tetsuo Noda,Junji Sagara,Shun'ichiro Taniguchi,Masafumi Takahashi +12 more
TL;DR: The results demonstrate the importance of the NLRP3 inflammasome in the initial inflammatory responses in AAA formation, indicating its potential as a novel therapeutic target for preventing AAA progression.
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Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice.
Fumitake Usui,Koumei Shirasuna,Hiroaki Kimura,Kazuki Tatsumi,Akira Kawashima,Tadayoshi Karasawa,Shigeaki Hida,Junji Sagara,Shun'ichiro Taniguchi,Masafumi Takahashi +9 more
TL;DR: The findings suggest that caspase-1 plays a critical role in vascular inflammation and atherosclerosis, and that modulation of caspASE-1 could be a potential target for prevention and treatment of Atherosclerosis.
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Blood flow: A key regulatory component of corpus luteum function in the cow
Akio Miyamoto,Koumei Shirasuna,Missaka P.B. Wijayagunawardane,Sho Watanabe,M. Hayashi,Dai Yamamoto,Motozumi Matsui,Tomas J. Acosta +7 more
TL;DR: It is shown for the first time that an acute increase in luteal BF occurs in the peripheral vasculature of the mature CL together with increases in eNOS expression and ET-1 and Ang II secretion in the CL during the early stages of luteolysis in the cow.
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NLRP3 Regulates Neutrophil Functions and Contributes to Hepatic Ischemia–Reperfusion Injury Independently of Inflammasomes
Yoshiyuki Inoue,Koumei Shirasuna,Hiroaki Kimura,Fumitake Usui,Akira Kawashima,Tadayoshi Karasawa,Kenji Tago,Katsuya Dezaki,Satoshi Nishimura,Junji Sagara,Tetsuo Noda,Yoichiro Iwakura,Hiroko Tsutsui,Shun'ichiro Taniguchi,Ken Yanagisawa,Toshihiko Yada,Yoshikazu Yasuda,Masafumi Takahashi +17 more
TL;DR: It is found that hepatic I/R stimuli upregulated the inflammasome-component molecule, nucleotide-binding oligomerization domain–like receptor (NLR) family pyrin domain–containing 3 (NLRP3), but not apoptosis-associated speck–like protein containing a caspase recruitment domain (ASC).
Journal ArticleDOI
Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages.
Tadayoshi Karasawa,Akira Kawashima,Fumitake Usui-Kawanishi,Sachiko Watanabe,Hiroaki Kimura,Ryo Kamata,Koumei Shirasuna,Yutaro Koyama,Ayana Sato-Tomita,Takashi Matsuzaka,Hiroshi Tomoda,Sam-Yong Park,Naoya Shibayama,Hitoshi Shimano,Tadashi Kasahara,Masafumi Takahashi +15 more
TL;DR: It is demonstrated that excess SFAs cause intracellular crystallization and subsequent lysosomal dysfunction, leading to the activation of the NLRP3 inflammasome, and provide novel insights into the pathogenesis of metabolic diseases.