K
Kowa Chen
Researcher at Memorial Hospital of South Bend
Publications - 14
Citations - 3218
Kowa Chen is an academic researcher from Memorial Hospital of South Bend. The author has contributed to research in topics: Fluorescence & Nanodiamond. The author has an hindex of 12, co-authored 14 publications receiving 3039 citations. Previous affiliations of Kowa Chen include Chang Gung University & National Taiwan University.
Papers
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Journal ArticleDOI
Characterization and application of single fluorescent nanodiamonds as cellular biomarkers
Chi-Cheng Fu,Hsu-Yang Lee,Kowa Chen,Tsong-Shin Lim,Hsiao-Yun Wu,Po-Keng Lin,Pei-Kuen Wei,Pei-Hsi Tsao,Huan-Cheng Chang,Wunshain Fann,Wunshain Fann +10 more
TL;DR: In this article, the authors presented the results of characterization and application of single fluorescent nanodiamonds as cellular biomarkers, and showed that under the same excitation conditions, the fluorescence of a single 35-nm diamond is significantly brighter than that of a simple dye molecule such as Alexa Fluor 546, which was photobleached in the range of 10 s at a laser power density of 104 W/cm2.
Characterization and applications of single fluorescent nanodiamonds as cellular biomarkers
Chi-Cheng Fu,Hsu-Yang Lee,Kowa Chen,Tsong-Shin Lim,Hsiao-Yun Wu,Po-Keng Lin,Pei-Kuen Wei,Pei-Hsi Tsao,Huan-Cheng Chang,Wunshain Fann +9 more
TL;DR: The feasibility of using surface-functionalized fluorescent nanodiamonds as single-particle biomarkers is demonstrated with both fixed and live HeLa cells, and the fluorescence of a single 35-nm diamond is significantly brighter than that of asingle dye molecule such as Alexa Fluor 546.
Journal ArticleDOI
Mass production and dynamic imaging of fluorescent nanodiamonds.
Yi Ren Chang,Hsu-Yang Lee,Kowa Chen,Chun-Chieh Chang,Dung-Sheng Tsai,Chi Cheng Fu,Tsong-Shin Lim,Tsong-Shin Lim,Yan-Kai Tzeng,Chia Yi Fang,Chia Yi Fang,Chau-Chung Han,Huan-Cheng Chang,Huan-Cheng Chang,Wunshain Fann,Wunshain Fann +15 more
TL;DR: In this article, it was shown that fluorescent nanodiamonds can be produced in large quantities by irradiating synthetic diamond nanocrystallites with helium ions, and the fluorescence is sufficiently bright and stable to allow three-dimensional tracking of a single particle within the cell by means of either one- or two-photon-excited fluorescence microscopy.
Journal Article
Mass production and dynamic imaging of fluorescent nanodiamonds
Yi Ren Chang,Hsu-Yang Lee,Kowa Chen,Chun-Chieh Chang,Dung-Sheng Tsai,Chi Cheng Fu,Tsong-Shin Lim,Yan-Kai Tzeng,Chia Yi Fang,Chau-Chung Han,Huan-Cheng Chang,Wunshain Fann +11 more
TL;DR: It is shown that bright fluorescent nanodiamonds can be produced in large quantities by irradiating synthetic diamond nanocrystallites with helium ions, and the fluorescence is sufficiently bright and stable to allow three-dimensional tracking of a single particle within the cell by means of either one- or two-photon-excited fluorescence microscopy.
Journal ArticleDOI
Microarray glycoprofiling of CA125 improves differential diagnosis of ovarian cancer
Kowa Chen,Aleksandra Gentry-Maharaj,Matthew Burnell,Catharina Steentoft,Lara Marcos-Silva,Lara Marcos-Silva,Ulla Mandel,Ian Jacobs,Ian Jacobs,Anne Dawnay,Usha Menon,Ola Blixt +11 more
TL;DR: It is suggested that microarray glycoprofiling could improve differential diagnosis and significantly reduce the number of patients elected for further testing and the approach warrants further investigation in other cancers.