K
Krista M. Hennig
Researcher at Harvard University
Publications - 15
Citations - 2830
Krista M. Hennig is an academic researcher from Harvard University. The author has contributed to research in topics: Histone deacetylase & Histone. The author has an hindex of 14, co-authored 14 publications receiving 2574 citations. Previous affiliations of Krista M. Hennig include University of Minnesota & Broad Institute.
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Journal ArticleDOI
An epigenetic blockade of cognitive functions in the neurodegenerating brain
Johannes Gräff,Damien Rei,Damien Rei,Ji-Song Guan,Ji-Song Guan,Wenyuan Wang,Wenyuan Wang,Jinsoo Seo,Jinsoo Seo,Krista M. Hennig,Krista M. Hennig,Thomas J.F. Nieland,Daniel M. Fass,Daniel M. Fass,Patricia F. Kao,M C Kahn,Susan C. Su,Susan C. Su,Alireza Samiei,Nadine F. Joseph,Nadine F. Joseph,Stephen J. Haggarty,Stephen J. Haggarty,Ivana Delalle,Li-Huei Tsai,Li-Huei Tsai +25 more
TL;DR: Reversing the build-up of histone deacetylase 2 by short-hairpin-RNA-mediated knockdown unlocks the repression of genes, reinstates structural and synaptic plasticity, and abolishes neurodegeneration-associated memory impairments.
An epigenetic blockade of cognitive functions in the neurodegenerating brain
Damien Rei,Ji-Song Guan,Wenyuan Wang,Jinsoo Seo,Krista M. Hennig,Thomas J.F. Nieland,Daniel M. Fass,Patricia F. Kao,M C Kahn,Susan C. Su,Alireza Samiei,Nadine F. Joseph,Stephen J. Haggarty,Ivana Delalle,Li-Huei Tsai,Johannes Gräff +15 more
Journal ArticleDOI
Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease.
Mark Kilgore,Courtney A. Miller,Daniel M. Fass,Daniel M. Fass,Krista M. Hennig,Krista M. Hennig,Stephen J. Haggarty,Stephen J. Haggarty,J. David Sweatt,Gavin Rumbaugh +9 more
TL;DR: Preclinical results indicate that targeted inhibition of class I HDAC isoforms is a promising avenue for treating the cognitive deficits associated with early stage AD.
Journal ArticleDOI
TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth
TL;DR: It is found that disruption of endocytosis leads to changes in TOR and phosphatidylinositol-3 kinase activity, affecting cell growth, autophagy, and rapamycin sensitivity.
Journal ArticleDOI
The Three-Dimensional Structure of the Autoproteolytic, Nuclear Pore-Targeting Domain of the Human Nucleoporin Nup98
Alec E. Hodel,Mary R. Hodel,Eric R. Griffis,Krista M. Hennig,Gary A. Ratner,Songli Xu,Maureen A. Powers +6 more
TL;DR: The three-dimensional structure of the C-terminal domain of hNup98 reveals a novel protein fold, and thus a new class of autocatalytic proteases, and reveals that the suggested nucleoporin RNA binding motif is unlikely to bind to RNA.