K
Krista Spiller
Researcher at University of Pennsylvania
Publications - 24
Citations - 2081
Krista Spiller is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Motor neuron. The author has an hindex of 16, co-authored 21 publications receiving 1652 citations. Previous affiliations of Krista Spiller include Janssen Pharmaceutica & Columbia University.
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Journal ArticleDOI
The Role of Macrophage Phenotype in Vascularization of Tissue Engineering Scaffolds
Kara L. Spiller,Rachel R. Anfang,Krista Spiller,Johnathan Ng,Kenneth R. Nakazawa,Jeffrey W. Daulton,Gordana Vunjak-Novakovic +6 more
TL;DR: It is shown that primary human M1 macrophages secrete the highest levels of potent angiogenic stimulators including VEGF, a chemoattractant for stabilizing pericytes and also promote anastomosis of sprouting endothelial cells in vitro.
Journal ArticleDOI
Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration
Artem Kaplan,Krista Spiller,Krista Spiller,Chris Towne,Kevin C. Kanning,Kevin C. Kanning,Ginn T. Choe,Ginn T. Choe,Adam Geber,Adam Geber,Turgay Akay,Patrick Aebischer,Christopher E. Henderson,Christopher E. Henderson +13 more
TL;DR: In ALS model mice expressing mutant superoxide dismutase (SOD1), reduction of MMP-9 function using gene ablation, viral gene therapy, or pharmacological inhibition significantly delayed muscle denervation and defined M MP-9 as a candidate therapeutic target for ALS.
Journal ArticleDOI
Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.
Krista Spiller,Clark R. Restrepo,Tahiyana Khan,Myrna A. Dominique,Terry C. Fang,Rebecca G. Canter,Chris Roberts,Kelly R. Miller,Richard M. Ransohoff,John Q. Trojanowski,Virginia M.-Y. Lee +10 more
TL;DR: Using an inducible mouse model of sporadic ALS, Spiller et al. show that spinal microgliosis is not a major feature of TDP-43-triggered disease, and microglia mediate T DP-43 clearance and motor recovery, suggesting a neuroprotective role in ALS.
Journal ArticleDOI
Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43
Adam K. Walker,Krista Spiller,Guanghui Ge,Allen Zheng,Yan Xu,Melissa Zhou,Kalyan Tripathy,Linda K. Kwong,John Q. Trojanowski,Virginia M.-Y. Lee +9 more
TL;DR: The rNLS mice are new TDP-43 mouse models that delineate the timeline of pathology development, muscle denervation and neuron loss in ALS/FTLD-TDP and show a significant increase in muscle innervation, a rescue of motor impairments, and a dramatic extension of lifespan.
Journal ArticleDOI
Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats.
Zheng-Xiong Xi,Krista Spiller,Arlene C. Pak,Jeremy G. Gilbert,Christopher Dillon,Xia Li,Xiao-Qing Peng,Eliot L. Gardner +7 more
TL;DR: In this article, the authors found that AM 251 (1-10 mg/kg), a novel CB1 receptor antagonist, dose-dependently lowered the break point for cocaine self-administration under a progressive-ratio (PR) reinforcement schedule in rats.