Kristian Jeppsson

TL;DR: A picture of how SMC complexes carry out their many functions starts to emerge when combining insights from ongoing analyses of their chromosomal binding, and how this interaction influences the structure and dynamics of chromosomes.

TL;DR: It is shown that the Dcdc2 protein localizes to the primary cilium in primary rat hippocampal neurons and that it can be found within close proximity to the ciliary kinesin-2 subunit Kif3a, consistent with a functional role in ciliary signaling.

TL;DR: It is demonstrated that the length of a chromosome influences the need of superhelical tension release in Saccharomyces cerevisiae, and a model where the Smc5/6 complex facilitates fork rotation by sequestering nascent chromatid intertwinings that form behind the replication machinery is proposed.

TL;DR: Using high-resolution ChIP-sequencing, it is shown that the chromosomal localization of Smc5/6 predicts the presence of the chromatid segregation-inhibiting entities which accumulate in top2-4 mutated cells, and indicates that, at least when Top2 is inhibited, Smc 5/6 facilitates their resolution.

TL;DR: Characterization of two temperature-sensitive mutants of NSE5 demonstrated the importance of Nse5 within the Smc5/6 complex for its stability and functionality at forks during hydroxyurea-induced replication stress, and supported the premise that Nse 5 is important for vital interactions between components within the SMC5/ 6 complex, and for its functionality during replication stress.