K
Katsuhiko Shirahige
Researcher at University of Tokyo
Publications - 250
Citations - 20918
Katsuhiko Shirahige is an academic researcher from University of Tokyo. The author has contributed to research in topics: Cohesin & Chromatin. The author has an hindex of 74, co-authored 240 publications receiving 18587 citations. Previous affiliations of Katsuhiko Shirahige include University of Nottingham & Osaka University.
Papers
More filters
Journal ArticleDOI
Cohesin mediates transcriptional insulation by CCCTC-binding factor
Kerstin S. Wendt,Keisuke Yoshida,Takehiko Itoh,Masashige Bando,Birgit Koch,Erika Schirghuber,Shuichi Tsutsumi,Genta Nagae,Ko Ishihara,Tsuyoshi Mishiro,Kazuhide Yahata,Fumio Imamoto,Hiroyuki Aburatani,Mitsuyoshi Nakao,Naoko Imamoto,Kazuhiro Maeshima,Katsuhiko Shirahige,Jan-Michael Peters +17 more
TL;DR: It is proposed that cohesin functions as a transcriptional insulator, and it is speculated that subtle deficiencies in this function contribute to ‘cohesinopathies’ such as Cornelia de Lange syndrome.
Journal ArticleDOI
S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex
Yuki Katou,Yutaka Kanoh,Masashige Bando,Hideki Noguchi,Hirokazu Tanaka,Toshihiko Ashikari,Katsunori Sugimoto,Katsuhiko Shirahige +7 more
TL;DR: It is demonstrated that the checkpoint regulatory proteins Tof1 and Mrc1 interact directly with the DNA replication machinery in Saccharomyces cerevisiae, which forms a stable pausing structure that serves to anchor subsequent DNA repair events.
Journal ArticleDOI
Cohesin relocation from sites of chromosomal loading to places of convergent transcription
Armelle Lengronne,Yuki Katou,Saori Mori,Saori Mori,Shihori Yokobayashi,Gavin Kelly,Takehiko Itoh,Yoshinori Watanabe,Katsuhiko Shirahige,Frank Uhlmann +9 more
TL;DR: High resolution analysis of cohesin association along budding yeast chromosomes III–VI finds that active transcription positions cohesIn at these sites, not the underlying DNA sequence, is found, suggesting that it is a common feature of eukaryotic chromosomes.
Journal ArticleDOI
Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair.
TL;DR: It is demonstrated that G2-phase repair also requires the presence of cohesin at the damage site, and evidence is provided that DSB induction elicits establishment of sister chromatid cohesion in G2, implicating that damage-recruited cohes in facilitates DNA repair by tethering chromatids.
Journal ArticleDOI
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle
Matthew A. Deardorff,Masashige Bando,Ryuichiro Nakato,Erwan Watrin,Takehiko Itoh,Masashi Minamino,Katsuya Saitoh,Makiko Komata,Yuki Katou,Dinah Clark,Kathryn E. Cole,Elfride De Baere,Christophe Decroos,Nataliya Di Donato,Sarah Ernst,Lauren J. Francey,Yolanda Gyftodimou,Kyotaro Hirashima,Melanie Hullings,Yuuichi Ishikawa,Christian Jaulin,Maninder Kaur,Tohru Kiyono,Patrick M. Lombardi,Laura Magnaghi-Jaulin,Geert Mortier,Naohito Nozaki,Michael B. Petersen,Hiroyuki Seimiya,Victoria Mok Siu,Yutaka Suzuki,Kentaro Takagaki,Jonathan J. Wilde,Patrick Willems,Claude Prigent,Gabriele Gillessen-Kaesbach,David W. Christianson,Frank J. Kaiser,Laird G. Jackson,Toru Hirota,Ian D. Krantz,Katsuhiko Shirahige +41 more
TL;DR: HDRAC8 is identified as the vertebrate SMC3 deacetylase, as well as loss-of-function HDAC8 mutations in six CdLS probands, which results in increased SMC 3 acetylation and inefficient dissolution of the ‘used’ cohesin complex released from chromatin in both prophase and anaphase.