K
Kristin A. Krukenberg
Researcher at Harvard University
Publications - 20
Citations - 1465
Kristin A. Krukenberg is an academic researcher from Harvard University. The author has contributed to research in topics: Protein structure & ATP hydrolysis. The author has an hindex of 15, co-authored 20 publications receiving 1233 citations. Previous affiliations of Kristin A. Krukenberg include University of California, San Francisco & Shire plc.
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Journal ArticleDOI
Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.
Ling Liu,Ling Liu,Xiaoyang Su,Xiaoyang Su,William J. Quinn,Sheng Hui,Kristin A. Krukenberg,Kristin A. Krukenberg,David W. Frederick,Philip Redpath,Le Zhan,Karthikeyani Chellappa,Eileen White,Marie E. Migaud,Marie E. Migaud,Timothy J. Mitchison,Joseph A. Baur,Joshua D. Rabinowitz,Joshua D. Rabinowitz +18 more
TL;DR: Flux analysis can reveal tissue-specific NAD metabolism and isotope-tracer methods for NAD flux quantitation are presented, which have shown versatility across tissues.
Journal ArticleDOI
Conformational dynamics of the molecular chaperone Hsp90.
TL;DR: The structural and biochemical studies leading to the current understanding of the conformational dynamics of Hsp90 are discussed, as well as the roles that nucleotide, co-chaperones, post-translational modification and substrates play.
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Multiple Conformations of E. coli Hsp90 in Solution: Insights into the Conformational Dynamics of Hsp90
TL;DR: This work used small-angle X-ray scattering and recently developed molecular modeling methods to characterize the solution structure of HtpG and demonstrate how it differs from known Hsp90 conformations, and provides a model for the role of nucleotide in effecting conformational change.
Journal ArticleDOI
Integration of small-angle X-ray scattering data into structural modeling of proteins and their assemblies.
Friedrich Förster,Benjamin Webb,Kristin A. Krukenberg,Hiro Tsuruta,David A. Agard,Andrej Sali +5 more
TL;DR: This work integrated SAXS profiles into software for modeling proteins and their assemblies by satisfaction of spatial restraints and modeled the quaternary structures of multidomain proteins with structurally defined rigid domains as well as quaternARY structures of binary complexes of structurallydefined rigid proteins.
Journal ArticleDOI
Intra- and Intermonomer Interactions Are Required to Synergistically Facilitate ATP Hydrolysis in Hsp90 *□
TL;DR: Data indicate that both the cis monomer and the trans monomers and the intradomain and interdomain interactions cooperatively stabilize the active conformation of each active site and help explain the importance of dimer formation.