L
Le Zhan
Researcher at Rutgers University
Publications - 18
Citations - 2319
Le Zhan is an academic researcher from Rutgers University. The author has contributed to research in topics: Farnesoid X receptor & Nuclear receptor. The author has an hindex of 14, co-authored 18 publications receiving 1430 citations. Previous affiliations of Le Zhan include University of Kansas.
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Journal ArticleDOI
Glucose feeds the TCA cycle via circulating lactate.
Sheng Hui,Jonathan M. Ghergurovich,Raphael J. Morscher,Cholsoon Jang,Xin Teng,Wenyun Lu,Lourdes A Esparza,Tannishtha Reya,Le Zhan,Jessie Yanxiang Guo,Eileen White,Joshua D. Rabinowitz,Joshua D. Rabinowitz +12 more
TL;DR: It is found that lactate can be a primary source of carbon for the TCA cycle and thus of energy, and during the fasted state, the contribution of glucose to tissue TCA metabolism is primarily indirect (via circulating lactate) in all tissues except the brain.
Journal ArticleDOI
Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.
Ling Liu,Ling Liu,Xiaoyang Su,Xiaoyang Su,William J. Quinn,Sheng Hui,Kristin A. Krukenberg,Kristin A. Krukenberg,David W. Frederick,Philip Redpath,Le Zhan,Karthikeyani Chellappa,Eileen White,Marie E. Migaud,Marie E. Migaud,Timothy J. Mitchison,Joseph A. Baur,Joshua D. Rabinowitz,Joshua D. Rabinowitz +18 more
TL;DR: Flux analysis can reveal tissue-specific NAD metabolism and isotope-tracer methods for NAD flux quantitation are presented, which have shown versatility across tissues.
Journal ArticleDOI
Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids
Michael D. Neinast,Cholsoon Jang,Cholsoon Jang,Sheng Hui,Danielle Murashige,Qingwei Chu,Raphael J. Morscher,Xiaoxuan Li,Le Zhan,Eileen White,Tracy G. Anthony,Joshua D. Rabinowitz,Zoltan Arany +12 more
TL;DR: In vivo isotopic tracing is employed to systemically quantify BCAA oxidation in healthy and insulin-resistant mice, finding that most tissues rapidly oxidize BCAAs into the tricarboxylic acid (TCA) cycle, with the greatest quantity occurring in muscle, brown fat, liver, kidneys, and heart.
Journal ArticleDOI
Autophagy maintains tumour growth through circulating arginine
Laura Poillet-Perez,Xiaoqi Xie,Le Zhan,Yang Yang,Daniel W. Sharp,Zhixian Sherrie Hu,Xiaoyang Su,Anurag Maganti,Cherry Jiang,Wenyun Lu,Haiyan Zheng,Marcus Bosenberg,Janice M. Mehnert,Jessie Yanxiang Guo,Edmund C. Lattime,Joshua D. Rabinowitz,Joshua D. Rabinowitz,Eileen White +17 more
TL;DR: It is shown that host-specific deletion of Atg7 impairs the growth of multiple allografted tumours, although not all tumour lines were sensitive to host autophagy status, and this identifies a metabolic vulnerability of cancer.
Journal ArticleDOI
Serine Catabolism Feeds NADH when Respiration Is Impaired.
Lifeng Yang,Juan Carlos Garcia Canaveras,Zihong Chen,Lin Wang,Lingfan Liang,Cholsoon Jang,Johannes A. Mayr,Zhaoyue Zhang,Jonathan M. Ghergurovich,Le Zhan,Shilpy Joshi,Zhixian Hu,Melanie R. McReynolds,Xiaoyang Su,Eileen White,Raphael J. Morscher,Joshua D. Rabinowitz +16 more
TL;DR: Deuterium-tracing studies in cultured cells and mice show that folate-dependent serine catabolism also produces substantial NADH, and when respiration is impaired, serineCatabolism contributes to toxic NADH accumulation.