K
Kristin L. DeBord
Researcher at University of Chicago
Publications - 12
Citations - 2265
Kristin L. DeBord is an academic researcher from University of Chicago. The author has contributed to research in topics: LcrV & Yersinia pestis. The author has an hindex of 11, co-authored 12 publications receiving 2187 citations. Previous affiliations of Kristin L. DeBord include University of California, Los Angeles.
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Journal ArticleDOI
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
Jochen Mattner,Kristin L. DeBord,Nahed Ismail,Randal D. Goff,Carlos Cantu,Dapeng Zhou,Pierre Saint-Mezard,Vivien Wang,Ying Gao,Ning Yin,Kasper Hoebe,Olaf Schneewind,David H. Walker,Bruce Beutler,Luc Teyton,Paul B. Savage,Albert Bendelac +16 more
TL;DR: Evidence is reported for microbial, antigen-specific activation of NKT cells against Gram-negative, lipopolysaccharide (LPS)-negative alpha-Proteobacteria such as Ehrlichia muris and Sphingomonas capsulata and shows that glycosylceramides are an alternative to LPS for innate recognition of the Gram- negative, LPS-negative bacterial cell wall.
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Iron-Source Preference of Staphylococcus aureus Infections
TL;DR: Stable isotope labeling was applied to detect source-specific iron by mass spectrometry and show that Staphylococcus aureus preferentially imports heme iron over transferrin iron, indicating that hemeIron is the preferred iron source during the initiation of infection.
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Plague Bacteria Target Immune Cells During Infection
TL;DR: It appears that Y. pestis disables these cell populations to annihilate host immune responses during plague, and selected immune cells for injection are selected.
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LcrV Plague Vaccine with Altered Immunomodulatory Properties
Katie A. Overheim,R. William DePaolo,Kristin L. DeBord,Elizabeth M. Morrin,Debra M. Anderson,Nathaniel M. Green,Robert R. Brubaker,Bana Jabri,Olaf Schneewind +8 more
TL;DR: It appears that LcrV variants with reduced immune modulatory properties could be used as a human vaccine to generate protective immunity against plague.
Journal ArticleDOI
Bacillus anthracis Sortase A (SrtA) Anchors LPXTG Motif-Containing Surface Proteins to the Cell Wall Envelope
Andrew H. Gaspar,Luciano A. Marraffini,Elizabeth M. Glass,Kristin L. DeBord,Hung Ton-That,Olaf Schneewind +5 more
TL;DR: Results suggest that B. anthracis SrtA anchors surface proteins bearing LPXTG motif sorting signals to the cell wall envelope of vegetative bacilli, which could be inhibited by thiol-reactive reagents, similar to staphylococcal sortases.