V
Vivien Wang
Researcher at Howard Hughes Medical Institute
Publications - 2
Citations - 1314
Vivien Wang is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Natural killer T cell & Antigen. The author has an hindex of 2, co-authored 2 publications receiving 1266 citations. Previous affiliations of Vivien Wang include University of Chicago.
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Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
Jochen Mattner,Kristin L. DeBord,Nahed Ismail,Randal D. Goff,Carlos Cantu,Dapeng Zhou,Pierre Saint-Mezard,Vivien Wang,Ying Gao,Ning Yin,Kasper Hoebe,Olaf Schneewind,David H. Walker,Bruce Beutler,Luc Teyton,Paul B. Savage,Albert Bendelac +16 more
TL;DR: Evidence is reported for microbial, antigen-specific activation of NKT cells against Gram-negative, lipopolysaccharide (LPS)-negative alpha-Proteobacteria such as Ehrlichia muris and Sphingomonas capsulata and shows that glycosylceramides are an alternative to LPS for innate recognition of the Gram- negative, LPS-negative bacterial cell wall.
Journal ArticleDOI
Liver Autoimmunity Triggered by Microbial Activation of Natural Killer T Cells
Jochen Mattner,Jochen Mattner,Paul B. Savage,Patrick S.C. Leung,Sabine Oertelt,Vivien Wang,Omita Trivedi,Seth T. Scanlon,Krishna Pendem,Luc Teyton,John Hart,William M. Ridgway,Linda S. Wicker,M. Eric Gershwin,Albert Bendelac +14 more
TL;DR: It is shown that infection of mice with N. aromaticivorans induced signature antibodies against microbial PDC-E2 and its mitochondrial counterpart but also triggered chronic T cell-mediated autoimmunity against small bile ducts, illustrating the importance of early microbial activation of NKT cells in the initiation of autonomous, organ-specific autoimmonity.