R
Randal D. Goff
Researcher at University of Wisconsin-Madison
Publications - 19
Citations - 1969
Randal D. Goff is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Natural killer T cell & CD1D. The author has an hindex of 12, co-authored 19 publications receiving 1891 citations. Previous affiliations of Randal D. Goff include Wisconsin Alumni Research Foundation & Brigham Young University.
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Journal ArticleDOI
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
Jochen Mattner,Kristin L. DeBord,Nahed Ismail,Randal D. Goff,Carlos Cantu,Dapeng Zhou,Pierre Saint-Mezard,Vivien Wang,Ying Gao,Ning Yin,Kasper Hoebe,Olaf Schneewind,David H. Walker,Bruce Beutler,Luc Teyton,Paul B. Savage,Albert Bendelac +16 more
TL;DR: Evidence is reported for microbial, antigen-specific activation of NKT cells against Gram-negative, lipopolysaccharide (LPS)-negative alpha-Proteobacteria such as Ehrlichia muris and Sphingomonas capsulata and shows that glycosylceramides are an alternative to LPS for innate recognition of the Gram- negative, LPS-negative bacterial cell wall.
Journal ArticleDOI
Effects of Lipid Chain Lengths in α-Galactosylceramides on Cytokine Release by Natural Killer T Cells
Randal D. Goff,Ying Gao,Jochen Mattner,Dapeng Zhou,Ning Yin,Carlos Cantu,Luc Teyton,and Albert Bendelac,Paul B. Savage +8 more
TL;DR: It is found that truncation of the phytosphingosine lipid chain increases the relative amounts of immunomodulatory cytokines released, and the length of the acyl chain in alpha-galactosylceramides influences cytokine release profiles.
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Probing the Aglycon Promiscuity of an Engineered Glycosyltransferase
TL;DR: This study highlights the ability of OleD variants to glucosylate a total of 71 diverse acceptors, catalyze iterative glycosylation with numerous substrates, and establishes OleD as the first multifunctional GT capable of generating O-, S- and N-glycosides.
Journal ArticleDOI
Synthesis and NKT cell stimulating properties of fluorophore- and biotin-appended 6"-amino-6"-deoxy-galactosylceramides.
† Xiao-Ti Zhou,Claire Forestier,Randal D. Goff,Chunhong Li,Luc Teyton,and Albert Bendelac,Paul B. Savage +6 more
TL;DR: To facilitate the elucidation of the structural features of glycolipids necessary for T cell stimulation, α-galactosylceramides have been prepared with small molecules appended at the C6 position of the sugar.
Journal ArticleDOI
Optimizing Glycosyltransferase Specificity via “Hot Spot” Saturation Mutagenesis Presents a Catalyst for Novobiocin Glycorandomization
TL;DR: A comprehensive two-phase "hot spot" saturation mutagenesis strategy for the rapid evolution of glycosyltransferase (GT) specificity for nonnatural acceptors is described, which rapidly led to improvements in the desired catalytic activity of several hundred-fold.