K
Kristina Wallenius
Researcher at AstraZeneca
Publications - 35
Citations - 2307
Kristina Wallenius is an academic researcher from AstraZeneca. The author has contributed to research in topics: Insulin resistance & Adipose tissue. The author has an hindex of 16, co-authored 30 publications receiving 2120 citations. Previous affiliations of Kristina Wallenius include Sahlgrenska University Hospital & University of Gothenburg.
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Journal ArticleDOI
Interleukin-6-deficient mice develop mature-onset obesity.
Ville Wallenius,Kristina Wallenius,Bo Ahrén,Mats Rudling,Hans Carlsten,Suzanne L. Dickson,Claes Ohlsson,John-Olov Jansson +7 more
TL;DR: In this article, the authors investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding interleukin-6 (Il6-/- mice) and found that they developed mature-onset obesity that was partly reversed by IL-six replacement.
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Intracerebroventricular interleukin-6 treatment decreases body fat in rats.
TL;DR: It is concluded that centrally administered IL-6 can decrease body fat in rats without causing acute-phase reaction.
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Reduced exercise endurance in interleukin-6-deficient mice.
Jenny Faldt,Ingrid Wernstedt,Sharyn M. Fitzgerald,Kristina Wallenius,Göran Bergström,John-Olov Jansson +5 more
TL;DR: IL-6(-/-) mice have reduced endurance and energy expenditure during exercise, suggesting that IL-6 is necessary for normal exercise capacity.
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Interleukin-6 Levels in the Central Nervous System Are Negatively Correlated with Fat Mass in Overweight/Obese Subjects
Kaj Stenlöf,Ingrid Wernstedt,Ted Fjällman,Ville Wallenius,Kristina Wallenius,John-Olov Jansson +5 more
TL;DR: CSF IL- 6 may be locally produced rather than serum derived, and body fat-regulating regions in the central nervous system may be exposed to insufficient IL-6 levels in more severe obesity.
Journal ArticleDOI
Liver-Derived IGF-I is of Importance for Normal Carbohydrate and Lipid Metabolism
Klara Sjögren,Kristina Wallenius,Jun-Li Liu,Mohammad Bohlooly-Y,Giovanni Pacini,Lennart Svensson,Jan Törnell,Olle Isaksson,Bo Ahrén,John-Olov Jansson,Claes Ohlsson +10 more
TL;DR: It is concluded that liver-derived IGF-I is of importance for carbohydrate and lipid metabolism.