K
Kristina Wehr
Researcher at Howard Hughes Medical Institute
Publications - 8
Citations - 2398
Kristina Wehr is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Drosophila Protein & Translational regulation. The author has an hindex of 8, co-authored 8 publications receiving 2304 citations. Previous affiliations of Kristina Wehr include European Bioinformatics Institute & Yale University.
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Journal ArticleDOI
A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation
Andrew T. McKie,Paola Marciani,Andreas Rolfs,Karen Brennan,Kristina Wehr,Dalna Barrow,Silvia Miret,Adrian Bomford,Tim J Peters,Farzin Farzaneh,Matthias A. Hediger,Matthias W. Hentze,Robert J. Simpson +12 more
TL;DR: The isolation and characterization of a novel cDNA (Ireg1) encoding a duodenal protein that is localized to the basolateral membrane of polarized epithelial cells are described and it is concluded that IREG1 represents the long-sought duodental iron export protein and is upregulated in the iron overload disease, hereditary hemochromatosis.
Journal ArticleDOI
Binary specification of nonsense codons by splicing and cytoplasmic translation
Rolf Thermann,Gabriele Neu-Yilik,Andrea Deters,Ute Frede,Kristina Wehr,Christian Hagemeier,Matthias W. Hentze,Andreas E. Kulozik +7 more
TL;DR: It is demonstrated that cells distinguish a premature termination codon within the β‐globin mRNA from the physiological translation termination codons by a two‐step specification mechanism, and a common principle for nonsense‐mediated decay from yeast to man is proposed.
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zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline.
TL;DR: The identification of Drosophila zucchini and squash, which function in germline RNAi processes, are reported, which shows that defects are due to the inability of zuc and squ mutants to produce repeat-associated small interfering RNAs.
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Specific isoforms of squid, a drosophila hnrnp, perform distinct roles in gurken localization during oogenesis
TL;DR: The results demonstrate the isoform-specific contributions of individual hnRNP proteins in the regulation of a specific mRNA, and suggest a novel role for hnRNPs in localization and translational regulation of mRNAs.
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Ribosomal Pausing and Scanning Arrest as Mechanisms of Translational Regulation from Cap-Distal Iron-Responsive Elements
TL;DR: Light is shed on a characteristic aspect of the IRE-IRP regulatory system and properties of the initiation and elongation translation apparatus of eukaryotic cells are uncovered.