K
Kristine M. Robinson
Researcher at Oregon State University
Publications - 8
Citations - 1603
Kristine M. Robinson is an academic researcher from Oregon State University. The author has contributed to research in topics: Peroxynitrite & Superoxide. The author has an hindex of 8, co-authored 8 publications receiving 1493 citations.
Papers
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Journal ArticleDOI
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes
Kristine M. Robinson,Michael S. Janes,Mariana Pehar,Jeffrey S. Monette,Meredith F. Ross,Tory M. Hagen,Michael P. Murphy,Joseph S. Beckman +7 more
TL;DR: It is found that the superoxide product of both HE and Mito-HE could be selectively excited at 396 nm with minimal interference from other nonspecific oxidation products, indicating the more selective detection of superoxide in vivo.
Journal ArticleDOI
Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants.
Patricia Cassina,Adriana Cassina,Mariana Pehar,Raquel Castellanos,Mandi Gandelman,Andrés de León,Kristine M. Robinson,Ronald P. Mason,Joseph S. Beckman,Luis Barbeito,Rafael Radi +10 more
TL;DR: Evidence that mitochondrial dysfunction in astrocytes critically influences motor neuron survival is provided and the potential pharmacological utility of mitochondrial-targeted antioxidants in ALS treatment is supported.
Journal ArticleDOI
The selective detection of mitochondrial superoxide by live cell imaging.
TL;DR: The dual wavelength imaging in live cells can be combined with immunocolocalization, which allows superoxide formation to be compared simultaneously in cocultures of two types of genetically manipulated cells in the same microscopic field.
Journal ArticleDOI
Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis
Mariana Pehar,Marcelo R. Vargas,Kristine M. Robinson,Patricia Cassina,Pablo Díaz-Amarilla,Tory M. Hagen,Rafael Radi,Luis Barbeito,Joseph S. Beckman +8 more
TL;DR: The data indicate that p75NTR-mediated motor neuron apoptosis involves ceramide-dependent increased mitochondrial superoxide production and cytochrome c release to the cytosol, and the mitochondria-targeted antioxidants mitoQ and mitoCP prevented neuronal loss, further evidencing the role of mitochondria in NGF-induced apoptosis.
Book ChapterDOI
Synthesis of Peroxynitrite from Nitrite and Hydrogen Peroxide
TL;DR: A simple method for the synthesis of peroxynitrite from nitrite and hydrogen peroxide that can generate hundreds of milliliters of 180 mM peroxlynitrite within 1 h from start to finish is reported.