J
Jeffrey S. Monette
Researcher at Oregon State University
Publications - 5
Citations - 911
Jeffrey S. Monette is an academic researcher from Oregon State University. The author has contributed to research in topics: Mitochondrion & Ceramide. The author has an hindex of 5, co-authored 5 publications receiving 840 citations. Previous affiliations of Jeffrey S. Monette include Linus Pauling Institute.
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Journal ArticleDOI
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes
Kristine M. Robinson,Michael S. Janes,Mariana Pehar,Jeffrey S. Monette,Meredith F. Ross,Tory M. Hagen,Michael P. Murphy,Joseph S. Beckman +7 more
TL;DR: It is found that the superoxide product of both HE and Mito-HE could be selectively excited at 396 nm with minimal interference from other nonspecific oxidation products, indicating the more selective detection of superoxide in vivo.
Journal ArticleDOI
Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart.
TL;DR: The deterioration in ETC supercomplexes may be an important underlying factor for both impaired mitochondrial function and loss of cardiac bioenergetics with age, and certain diseases display similar supercomplex destabilization as the results for aging.
Journal ArticleDOI
(R)-α-Lipoic Acid Treatment Restores Ceramide Balance in Aging Rat Cardiac Mitochondria
Jeffrey S. Monette,Luis A. Gómez,Régis F. Moreau,Kevin C. Dunn,J. A. Butler,Liam A. Finlay,Alexander J. Michels,Kate Petersen Shay,Eric J. Smith,Tory M. Hagen +9 more
TL;DR: LA treatment lowers ceramide levels to that seen in young rat heart mitochondria and restores Complex IV activity which otherwise declines with age, and reverses the age-associated decline in glutathione levels and concomitantly improved complex IV activity.
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R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.
Liam A. Finlay,Alex J. Michels,Judy Ann Butler,Eric J. Smith,Eric J. Smith,Jeffrey S. Monette,Jeffrey S. Monette,Régis F. Moreau,Régis F. Moreau,Shay Kate Petersen,Balz Frei,Balz Frei,Tory M. Hagen,Tory M. Hagen +13 more
TL;DR: It is concluded that advanced age is associated with a necroinflammatory phenotype and increased lipid synthesis, while chronic LA supplementation influences hepatic genes associated with lipid and energy metabolism and circadian rhythm, regardless of age.
Journal ArticleDOI
Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations
Jeffrey S. Monette,Luis A. Gómez,Régis F. Moreau,Brett A. Bemer,Alan W. Taylor,Tory M. Hagen +5 more
TL;DR: Overall, mitochondrial sphingolipid content reflected levels seen in cardiac tissue, but the specific ceramide distribution distinguished IFM and SSM from each other.