M
Meredith F. Ross
Researcher at Wellcome Trust
Publications - 12
Citations - 1954
Meredith F. Ross is an academic researcher from Wellcome Trust. The author has contributed to research in topics: Mitochondrion & MitoQ. The author has an hindex of 11, co-authored 12 publications receiving 1809 citations. Previous affiliations of Meredith F. Ross include University of Cambridge & Medical Research Council.
Papers
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Journal ArticleDOI
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes
Kristine M. Robinson,Michael S. Janes,Mariana Pehar,Jeffrey S. Monette,Meredith F. Ross,Tory M. Hagen,Michael P. Murphy,Joseph S. Beckman +7 more
TL;DR: It is found that the superoxide product of both HE and Mito-HE could be selectively excited at 396 nm with minimal interference from other nonspecific oxidation products, indicating the more selective detection of superoxide in vivo.
Journal ArticleDOI
Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology.
Meredith F. Ross,Geoffrey F. Kelso,Frances H. Blaikie,Andrew M. James,Helena M. Cochemé,Aleksandra Filipovska,T Da Ros,Thomas R. Hurd,Robin A.J. Smith,Michael P. Murphy +9 more
TL;DR: Why Lipophilic phosphonium cations are useful in mitochondrial research and some of the ways in which they are now being utilized are outlined.
Journal ArticleDOI
Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells
Meredith F. Ross,Tracy A. Prime,Irina Abakumova,Andrew M. James,Carolyn M. Porteous,Robin A.J. Smith,Michael P. Murphy +6 more
TL;DR: The strong influence of hydrophobicity on TPP cation uptake into mitochondria within cells facilitates the rational design of mitochondria-targeted compounds to report on and modify mitochondrial function in vivo.
Journal ArticleDOI
Mitochondrial targeting of quinones: therapeutic implications.
Helena M. Cochemé,Geoffrey F. Kelso,Andrew M. James,Meredith F. Ross,Jan Trnka,Thabo Mahendiran,Jordi Asin-Cayuela,Frances H. Blaikie,Abdul-Rahman B. Manas,Carolyn M. Porteous,Victoria J. Adlam,Robin A.J. Smith,Michael P. Murphy +12 more
TL;DR: MitoQ protects mitochondria against oxidative damage in vitro and following oral delivery, and may therefore form the basis for mitochondria-protective therapies.
Journal ArticleDOI
Mitochondria-targeted antioxidants in the treatment of disease.
Robin A.J. Smith,Victoria J. Adlam,Frances H. Blaikie,Abdul-Rahman B. Manas,Carolyn M. Porteous,Andrew M. James,Meredith F. Ross,Angela Logan,Helena M. Cochemé,Jan Trnka,Tracy A. Prime,Irina Abakumova,Bruce A. Jones,Aleksandra Filipovska,Michael P. Murphy +14 more
TL;DR: Some of the work done to date on mitochondria‐targeted antioxidants that selectively block mitochondrial oxidative damage and prevent some types of cell death are outlined and how they may be developed as therapies are outlined.