K
Kristine Metzger
Researcher at Katholieke Universiteit Leuven
Publications - 7
Citations - 1801
Kristine Metzger is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Pyruvate carboxylase & PARL. The author has an hindex of 7, co-authored 7 publications receiving 1687 citations.
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Journal ArticleDOI
Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling
Sara Cipolat,Tomasz Rudka,Dieter Hartmann,Veronica Costa,Lutgarde Serneels,Katleen Craessaerts,Kristine Metzger,Christian Frezza,Wim Annaert,Luciano D'Adamio,Carmen Derks,Tim Dejaegere,Luca Pellegrini,Rudi D'Hooge,Luca Scorrano,Bart De Strooper +15 more
TL;DR: Findings implicate regulated intramembrane proteolysis in controlling apoptosis in Parl-/- mice, substantiating the importance of PARL in OPA1 processing.
Journal Article
Mitochondrial rhomboid parl regulates cytochrome c release during apoptosis via OPA1 dependent cristae remodeling
Sara Cipolat,Tomasz Rudka,Dieter H. Hartmann,Costa,S. Serneels,Kathleen Craessaerts,Kristine Metzger,Luca Scorrano,Bart De Strooper +8 more
TL;DR: Parl-associated rhomboid-like (PARL-like) as mentioned in this paper is an inner mitochondrial membrane rhomboids of unknown function, whose yeast ortholog is involved in mitochondrial fusion.
Journal ArticleDOI
Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis
Stefan Christen,Doriane Lorendeau,Roberta Schmieder,Dorien Broekaert,Kristine Metzger,Koen Veys,Ilaria Elia,Joerg Martin Buescher,Martin F. Orth,Shawn M. Davidson,Thomas G. P. Grunewald,Katrien De Bock,Sarah-Maria Fendt +12 more
TL;DR: In this paper, the authors measured PC-dependent anaplerosis in breast-cancer-derived lung metastases compared to their primary cancers using in-vivo 13C tracer analysis.
Journal ArticleDOI
Chemical Synthesis of (S)-4,5-Dihydroxy-2,3-pentanedione, a Bacterial Signal Molecule Precursor, and Validation of Its Activity in Salmonella typhimurium
Sigrid C. J. De Keersmaecker,Csaba Varszegi,Nadja van Boxel,Lothar W. Habel,Kristine Metzger,Ruth Daniels,Kathleen Marchal,Dirk De Vos,Jos Vanderleyden +8 more
TL;DR: An original, short, and convenient chemical synthesis of enantiopure (S)-4,5-dihydroxy-2,3-pentanedione (DPD) is described, starting from commercial methyl-(-)-2,2-dimethyl-1, 3-dioxolane-4-carboxylate and synthesized biologically active DPD.
Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis
Stefan Christen,Doriane Lorendeau,Roberta Schmieder,Dorien Broekaert,Kristine Metzger,Koen Veys,Ilaria Elia,Joerg Martin Buescher,Martin F. Orth,Shawn M. Davidson,Thomas G. P. Grunewald,Katrien De Bock,Sarah-Maria Fendt +12 more
TL;DR: It is shown that breast cancer cells proliferating as lung metastases activate PC-dependent anaplerosis in response to the lung microenvironment, and it is found that mitochondrial pyruvate concentrations can promote PC- dependent anaplosis via enzyme kinetics.