K
Kumi Kawai
Researcher at Nagoya University
Publications - 43
Citations - 2480
Kumi Kawai is an academic researcher from Nagoya University. The author has contributed to research in topics: Glial cell line-derived neurotrophic factor & Tyrosine. The author has an hindex of 25, co-authored 42 publications receiving 2302 citations. Previous affiliations of Kumi Kawai include University of California, Berkeley & Aichi Medical University.
Papers
More filters
Journal ArticleDOI
Akt/PKB Regulates Actin Organization and Cell Motility via Girdin/APE
Atsushi Enomoto,Hideki Murakami,Naoya Asai,Nobuhiro Morone,Takashi Watanabe,Kumi Kawai,Yoshiki Murakumo,Jiro Usukura,Kozo Kaibuchi,Masahide Takahashi +9 more
TL;DR: This work identifies an Akt substrate, designated Girdin/APE (Akt-phosphorylation enhancer), which is an actin binding protein, which plays a crucial role in the formation of stress fibers and lamellipodia.
Journal ArticleDOI
Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor.
Hironori Hayashi,Masatoshi Ichihara,Toshihide Iwashita,Hideki Murakami,Yohei Shimono,Kumi Kawai,Kei Kurokawa,Yoshiki Murakumo,Tsuneo Imai,Hiroomi Funahashi,Akimasa Nakao,Masahide Takahashi +11 more
TL;DR: It is suggested that the RAS and PI3-K pathways activated by GDNF bifurcate mainly through SHC bound to tyrosine 1062 in RET, which is important for activation of CREB and NF-κB in GDNF-treated cells, respectively.
Journal ArticleDOI
A Targeting Mutation of Tyrosine 1062 in Ret Causes a Marked Decrease of Enteric Neurons and Renal Hypoplasia
Mayumi Jijiwa,Toshifumi Fukuda,Toshifumi Fukuda,Kumi Kawai,Akari Nakamura,Kei Kurokawa,Yoshiki Murakumo,Masatoshi Ichihara,Masahide Takahashi +8 more
TL;DR: It is demonstrated that the signal via tyrosine 1062 plays an important role in histogenesis of the enteric nervous system and nephrogenesis.
Journal ArticleDOI
The RET proto-oncogene: a molecular therapeutic target in thyroid cancer.
Yoshinori Kodama,Naoya Asai,Kumi Kawai,Mayumi Jijiwa,Yoshiki Murakumo,Masatoshi Ichihara,Masahide Takahashi +6 more
TL;DR: The RET proto‐oncogene and some signaling molecules that function downstream of RET could be potential targets for the development of selective cancer therapeutics.
Journal ArticleDOI
Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma
Toshihide Iwashita,Masashi Kato,Hideki Murakami,Naoya Asai,Yoshihiro Ishiguro,Shinji Ito,Yosuke Iwata,Kumi Kawai,Masami Asai,Kei Kurokawa,Hiroshi Kajita,Masahide Takahashi +11 more
TL;DR: Interestingly, the level of transforming activity correlated with clinical phenotypes; high group RET with the A883F or M918T mutation and low group Ret with the E768D, V804L or S891A mutation were associated with the development of MEN 2B and FMTC, respectively.